摘要
目的 :观察甲状腺内注射氟美松治疗亚急性甲状腺炎的有效性和安全性。方法 :2 0例亚急性甲状腺炎患者随机分为两组 ,A组 (1 0例 )予氟美松注射液 (5mg/ml,2次 /wk)甲状腺内局部注射 ,B组口服泼尼松 (3 0mg/d) ,治疗后 2wk、4wk、8wk比较其临床结果。结果 :8wk时A组治愈率为 90 % ,B组治愈率 1 0 0 % ,两组比较无显著性差异 (P >0 2 5 )。A组疗程为 (5 6± 2 1 )wk ,B组为 (8 2±1 8)wk ,两组比较有显著性差异 (P <0 0 5 )。结论 :甲状腺局部注射氟美松治疗亚急性甲状腺炎改善症状快 ,且可以缩短疗程 。
OBJECTIVE:To investigate the efficacy and safety of topical intrathyroid injection of dexamethasone in the patients with subacute thyroiditis.METHODS:Twenty patients with subacute thyroiditis were divided randomly into two groups.10 Patients (group A) were treated with topical intrathyroid injection of dexamethasone(5mg/ml,twice perweek),10 Patients (group B)were treated with prednisone 30 mg/d orally.Clinical outcomes of two groups are compared after 2 weeks,4 weeks and 8 weeks.RESULTS:Curative rate of group A and group B after 8 weeks were 90% and 100% respectively and there were no significant difference( P >0.25).Duration of therapy were(5.6±2.1) weeks in group A and (8.2±1.8) weeks in group B respectively and there were significant difference ( P <0.05).No adverse reactions occurred in both groups.CONCLUSIONS:Topical injection of dexamethasone in patients with subacute thyroiditis improves the symptoms rapidly and shorten the course of disease,so it is highly effective and safe.
出处
《药学实践杂志》
CAS
2000年第3期134-136,共3页
Journal of Pharmaceutical Practice
关键词
亚急性甲状腺炎
氟美松
甲状腺内注射
subacute thyroditis
thyroid
dexamethasone
topical therapy
