摘要
目的分析福州地区健康体检女性人乳头瘤病毒（human papillomavirus，HPV）的亚型分布特点，为宫颈癌防治、HPV疫苗的开发与应用提供借鉴依据。方法对2010年3月～2011年11月来福建第二人民医院体检中心妇科体检的女性2017例，采集宫颈脱落细胞，采用基因芯片技术，进行常见23种HPVDNA亚型（包括18种高危型和5种低危型）的分型检测，分析HPV感染率、亚型、多重感染等特征；并对其中1493例，以5岁为一年龄段，分析HPV感染的年龄分布特点。结果在2017例标本中，共检出HPV阳性632例，检出率为31．33％。高危型以HPV52（6．89％），HPV16（6％），HPV58（5．5％），HPV66（2．77％）和HPV51（2．57％）为常见；低危型以HPV11（4．27％）和HPV6（4．11％）为常见。单一型别感染检出率为17．35％（350／2017），单一高危型感染的比例（13．29％）高于单一低危型感染的比例（4．06％）。多重（2种或2种型别以上）感染检出率为13．98％（282／2017），表现为多重高危感染（7．33％）和多重高低危混合感染（6．64％）。在1493例中，以20-49岁年龄为主，占所有送检标本的93．5％。两个感染率的高峰为20～24岁（7．64％）和35～39岁（6．63％）。结论福州地区HPV感染以高危型为主，前5位的亚型是HPV52，16，58，11和6。多重感染以二重和三重感染最常见，感染高峰在20～24岁。
Objective To investigate the prevalence and genotypes distribution of human papillomavirus （HPV） infection in health-check female cervix in Fuzhou area, so as to provide the strategy for prevention and treatment of cervical cancer in the future. Methods 2 017 females,who visited Center for Health Check of Fujian Second People＇s Hospital,for gynecological examination,were recruited. From cervical cast-off cells,gene chip technique was used to detect HPV-23 types,including 18 High-risk （HR） type and 5 low-risk （LR） types. The infection rate,genotypes,multiple-types of HPV infection were analyzed. And age distribution of HPV infection were further investigated in 1 493 females, as 5 years old for one age group. Resuits In 2 017 cases, the overall prevalence of HPV infection was 31.33. % （632 /2017）. HPV52, the most common HR type,was detected in 6.89% ,followed by HPV16（6%）, HPV58 （5.5%）, HPV66 （2.77%） and HPVS1 （2.57%）. HPV11 （4.27%） and HPV6（4.11%） were the most frequent LR types. In 632 cases of HPV infection,350 cases （17.35%） were single-type infection. The rate of HR was 13.29% （268 cases） ,more than the rate of LR （4.06%, 82 cases） in the single infection. The prevalence of multiple-type infection was 13.98% （282 cases） ,7.33% for multiple HR infection and 6.64% for multiple HR-LR infection,respectively. In 1 493 cases,93.5% of the specimen was from the age groups of 20 to 49 years old. And the prevalence was highest in the age group of 20-24 years old （7.64%） ,followed by the age group of 35-39 years old （6.63%）. Conclusion In this survey, HR genotypes were the main types in HPV infection in Fuzhou area. The most prevalent HPV types were HPV52,16,58,11 and 6. Doubleand Triple-types infection were predominated in multiple HPV infection. The peak prevalence was in the age group of 20-24 years old.
出处
《现代检验医学杂志》
CAS
2012年第3期43-45,48,共4页
Journal of Modern Laboratory Medicine
