摘要
目的了解代谢综合征(MS)及其各组分与前列腺癌发病风险之间的关系。方法回顾性分析2003年9月—2009年9月福建医科大学附属协和医院收治的211例前列腺癌患者(前列腺癌组)的临床资料,包括年龄、身高、体重、血压、空腹血糖、前列腺特异性抗原(PSA)、三酰甘油、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及总胆固醇水平。随机选取同期同一年龄段在门诊进行体格检查的非前列腺疾病人群215名(NPG组)及良性前列腺增生(BPH)患者215例(BPH组)作为对照。结果前列腺癌组的MS发病率为16.6%(35/211),显著低于NPG组的24.7%(53/215,P=0.04),与BPH组18.6%(40/215)的差异无统计学意义(P=0.585)。前列腺癌、BPH和NPG组3组间平均年龄的差异无统计学意义(P>0.05)。前列腺癌组与BPH组间MS各诊断指标构成比的差异均无统计学意义(P值均>0.05)。前列腺癌组与NPG组间除血压构成比的差异无统计学意义(P>0.05)外,体质指数(BMI)、空腹血糖、三酰甘油、血浆总胆固醇、HDL-C、LDL-C构成比的差异均有统计学意义(P值均<0.05)。单因素及多因素非条件Logistic回归分析结果显示,MS(OR=0.594,95%CI为0.368～0.960,P=0.033)、MS组分数量(OR=0.828,95%CI为0.701～0.978,P=0.026)及高水平三酰甘油(OR=0.521,95%CI为0.320～0.850,P<0.05)是罹患前列腺癌的保护因素,正常空腹血糖和低水平HDL-C是罹患前列腺癌的危险因素(OR=6.318、5.898,95%CI为4.035～9.892、2.593～13.415,P值均<0.05),BMI、高血压、血浆总胆固醇及LDL-C水平与罹患前列腺癌无关(P值均>0.05)。结论前列腺癌患者的代谢水平与BPH患者相似,但与非前列腺疾病人群存在显著差异。MS可能是前列腺癌的保护性因素,随着MS组分数量的增多,患前列腺癌的风险将减小。低水平HDL-C可能是前列腺癌的危险因素,高血糖、高三酰甘油水平可能是前列腺癌的保护性因素,BMI及血压与前列腺癌的发生无明显相关性。
Objective To assess the relation between metabolic syndrome （MS） with its components and risk of prostate cancer. Methods A retrospective study was conducted in 211 prostate cancer patients treated from September 2003 to September 2009. The clinical data including age, height, weight, blood pressure, fasting blood glucose, prostate specific antigen （PSA）, serum triglyceride （TG）, high density lipoprotein cholesterol （HDL-C）, low density lipoprotein cholesterol （LDL-C） and serum total cholesterol （TC） were reviewed. Meanwhile, we randomly selected 215 non-prostate disease （NPG） people for physical examination in the out-patient department and 215 benign prostatic hyperplasia （BPH） patients as control group. Results The MS incidence in prostate cancer group was significantly lower than that in NPG group （16.6% [35/211] vs. 24.7% [53/215], P=0.04）, but not statistically different from BPH group （18.6% [40/215], P=0.585）. There was no statistical difference in age among the 3 groups （P0.05）. There were no statistical differences in body mass index （BMI）, blood pressure, fasting blood glucose, HDL-C, TG, TC and LDL-C between the prostate cancer group and the BPH group （P0.05）. All the indices exceptfor blood pressure between the prostate cancer group and the NPG group had statistical difference （P0.05）. The univariate and multivariate non-conditional logistic regression analysis showed that there was a negative correlation between MS and prostate cancer （OR=0.594, 95%CI=0.368~0.960, P=0.033）, and between the number of components of MS and the incidence of prostate cancer （OR=0.828, 95%CI=0.701~0.978, P=0.026）. Normal fasting blood glucose and low HDL-C level was positively correlated with the incidence of prostate cancer （OR=6.318, 5.898; 95%CI=4.035~9.892, 2.593~13.415; P0.05）, but high TG level was negatively correlated with the incidence of prostate cancer （OR=0.521, 95%CI=0.320~0.850, P0.05）. BMI, high blood pressure, TC and LDL-C were not correlated with the incidence of prostate cancer （P0.05）. Conclusion The metabolic level of the prostate cancer patients is similar with that of BPH patients, but significantly different with NPG people. MS may be a protective factor for the incidence of prostate cancer. The more components of MS are, the lower risk of prostate cancer is. Low HDL-C may be a risk factor, but high blood glucose and TG may be protective factors for prostate cancer. BMI and blood pressure are not obviously related to prostate cancer.
出处
《上海医学》
CAS
CSCD
北大核心
2012年第5期392-395,共4页
Shanghai Medical Journal
