摘要
目的探讨Survivin、基质金属蛋白酶-9(MMP-9)和血管内皮生长因子(VEGF)在结肠癌组织中的表达及其与肿瘤进展的关系。方法采用免疫组化SP法检测60例结肠癌组织中Survivin、MMP.9和VEGF表达情况,并以25例正常结肠组织作为对照。结果结肠癌组织中Survivin、MMP-9和VEGF表达显著高于正常结肠组织(P〈0.05)。结肠癌患者中Ⅲ-Ⅳ期、淋巴结转移患者的Survivin、MMP-9和VEGF阳性表达率分别高于Ⅰ-Ⅱ期和无淋巴结转移患者(P〈0.05)。结论结肠癌组织中Survivin、MMP-9和VEGF的表达水平明显升高。在结肠癌的浸润转移中起到了重要的作用,可作为反映结肠癌进展的生物学指标。
Objective To investigate the expression and clinical significance of Survivin, matrix metalloproteinase(MMP-9) and vascular endothelial growth factor(VEGF) in colonic carcinoma tissue and its relationship with tumor progress. Methods The expression levels of Survivin, MMP-9 and VEGF were measured by immunohistochemistry in the resected specimens from 60 patients with colonic carcinoma and 25 controls. Results The positive rates of Survivin, MMP-9 and VEGF were significantly higher in the co- lonic carcinoma patients than those in 'controls (P 〈 0. 05). The positive rates of Survivin, MMP-9 and VEGF in Ⅲ-Ⅳ stage were significantly higher than those of patients in Ⅰ-Ⅱ stage tumor (P 〈 O. 05 ). The positive rates of Survivin, MMP-9 and VEGF in lymph node metastasis tumor were significantly higher than those of patients in non metastasis tumor (P 〈 0. 05). Conclusions Survivin, MMP-9 and VEGF expression in colonic carcinoma increases markedly and play an important role in the progression of colonic carcinoma.
出处
《中国实用医刊》
2012年第16期8-9,共2页
Chinese Journal of Practical Medicine