摘要
目的 观察神经节苷酯治疗新生儿缺血缺氧性脑病（HIE）的临床疗效及其对神经特异性烯醇化酶（NSE）的影响.方法 65例HIE患儿随机分为对照组30例和治疗组35例,对照组给予常规治疗,治疗组在对照组的基础上加用神经节苷酯.观察两组患儿的临床疗效及指标恢复正常时间,并比较两组患儿治疗前后NSE水平.结果 治疗组总有效率88.6%,对照组73.3%,差异有统计学意义（P〈0.05）;治疗组患儿临床指标恢复正常时间早于对照组,差异有统计学意义（P〈0.05或P〈0.01）;治疗组治疗后NSE水平较治疗前下降比对照组更为明显（P〈0.05）.结论 神经节苷酯治疗HIE的临床疗效明显,并可降低NSE水平.
Objective To observe the clinical effect of Ganglioside on neonates with hypoxie-ischemic encephalopathy （ HIE ） and its impact on neuron-specific enolase （ NSE ） . Methods 65 neonates with HIE were randomly divided into the control group （ n=30 ） and treatment group （ n=35 ） . The control group received conventional therapy and the treatment group added Ganglioside on the basis of the control group. The clinical effect and clinical symptoms recovery time of the two groups were observed, and the level of NSE before and after treatment of the two groups was compared. Results The total effective rate was 88.6% in the treatment group, which was significantly higher than that in the control group （ P〈0.05 ） . Compared with the control group, the recovery time of clinical symptoms in the treatment gorup were significant shorter. （ P〈0.05, P〈0.01 ） and the NSE level after treatment declined more significantly （P〈0.05） . Conclusion The clinical effect of ganglioside treatment on HIE is obvious and it can reduce the levels of NSE
出处
《浙江临床医学》
2012年第8期914-915,共2页
Zhejiang Clinical Medical Journal
