摘要
目的制备长春新碱固体脂质纳米粒(VCR-SLN)并优化其处方组成和制备工艺。方法单因素考察筛选载体、稳定剂及制备工艺,用正交试验进行优化,以包封率、载药量和粒径为指标,筛选最佳处方和制备工艺,并对在优化条件下制备的VCR-SLN进行质量评价。结果以单硬酸酯甘油酯为载体,大豆卵磷脂、泊洛沙姆188为乳化剂,采用复乳-溶剂扩散法制备得VCR-SLN,其平均粒径为156.3 nm,包封率为55.12%,载药量为3.09%。结论复乳-溶剂扩散法适用于制备VCR-SLN。
Objective To prepare and optimize the composition of vincristine solid lipid nanoparticles（VCR-SLN）.Methods According to different variables of carrier,emulsifier and preparation,the orthogonal experiment was designed to seek best prescription and preparation process,the entrapment efficiency;drug loading and particles size were taken as criteria.Then the obtained VCR-SLN were evaluated.Results With biodegradable type material glycerin monostearate as a carrier,and soy lecithin and Poloxamer 188 as emulsifier,using multiple emulsion-solvent diffusion technique to prepare solid lipid nanoparticles（SLN） of vincristin,VCR-SLN were spherelike and smooth,particles size is 156.3 nm,entrapment efficiency is 55.12%,drug loading capacity is 3.09%.Conclusion Multiple emulsion-solvent diffusion technique could be used to prepare VCR-SLN.
出处
《中国药业》
CAS
2012年第15期59-61,共3页
China Pharmaceuticals
基金
浙江省台州市科技计划项目
项目编号:100KY02
关键词
制备工艺
长春新碱
固体脂质纳米粒
正交试验
preparation
vincristin
solid lipid nanoparticles
orthogonal experiment
