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鹅膏毒肽与RNA聚合酶Ⅱ相互作用的研究进展 被引量：8

Progress in Research on the Interaction Between Amanitins and RNA Polymerase Ⅱ
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摘要 RNA聚合酶Ⅱ是真核生物中最活跃最复杂的RNA聚合酶之一,具有非常重要的生物学功能,而鹅膏(Amanita)毒肽对其活性具有专一的高抑制性,这使鹅膏毒肽与RNA聚合酶Ⅱ相互作用的研究尤为重要。鉴于国内对鹅膏毒肽与RNA聚合酶Ⅱ相互作用的研究薄弱,笔者从鹅膏毒肽活性位点的确定、两者相互作用方式、抑制机理及抑制能力等方面进行总结,以期为两者的深入研究提供参考。 Amanitin toxins are specific inhibitors of RNA polymerase Ⅱ.This review describes recent progress in research aimed at improving our understanding of the interactions between the amanitins and RNA polymerase Ⅱ at the molecular level.The report,in four parts,describes the identification of amanitin active sites,the interactions between the amanitins and RNA polymerase Ⅱ,the underlying inhibitory mechanism（s） and the inhibitory capacities associated with the different toxins.
作者 张蕊 图力古尔
机构地区 山东省食用菌技术重点实验室
出处 《食用菌学报》 北大核心 2012年第2期111-116,F0003,共7页 Acta Edulis Fungi
基金 "泰山学者"建设专项基金 山东省优秀中青年科学家奖励基金(编号:BS2011SW002) 鲁东大学人才引进基金(编号:LY2011017)的部分研究内容
关键词 鹅膏毒肽 RNA聚合酶Ⅱ 晶体结构 抑制性 Amanitin RNA polymerase Ⅱ crystal structure enzyme inhibition
分类号 R341 [医药卫生—基础医学]
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参考文献28

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共引文献50

同被引文献64

  • 1宋昆,肖桂林.鹅膏毒蕈的毒素分类和中毒机制概况[J].湖南中医药导报,2004,10(8):52-54. 被引量：5
  • 2杨聪,刘云祥,陈文生.人有机阴离子OATPs在药物分布中的作用研究进展[J].西南国防医药,2010,20(6):672-674. 被引量：1
  • 3李玉白,全建设,刘劭钢.鹅膏毒肽致肝脏损伤的生化指标探讨[J].实用医学杂志,2006,22(3):252-253. 被引量：5
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引证文献8

二级引证文献56

食用菌学报
2012年 第2期

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