摘要
CC类人类趋化因子受体4(CCR4)是趋化因子家族中具有7个跨膜结构的G蛋白偶联受体。CCR4受体与自身免疫性疾病、哮喘、特应性皮炎等多种疾病的形成和发展有关,可成为这些疾病新的治疗靶点,受到越来越多学者的关注。CCR4拮抗剂的研究成为研发治疗上述疾病药物新热点。本文对近年来小分子CCR4拮抗剂的研究进展进行综述。
CC chemokine receptor 4 （CCR4） is one of the G-protein-coupled receptors with a characteristic seven-transmembrane structure. CCR4 plays an important role in the formation and development of autoimmune diseases, asthma, atopic dermatitis, etc. , which has caused more and more attention of scholars. CCR4 can be used as a novel choice for treating such diseases. In this paper, the advances in the research on small molecule CCR4 antagonists are reviewed.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2012年第14期1616-1620,1650,共6页
Chinese Journal of New Drugs
基金
吉林大学种子基金项目(450060322111)
