期刊文献+

冠状动脉支架术后血浆超敏C-反应蛋白水平变化 被引量:2

下载PDF
导出
摘要 目的研究冠状动脉支架术后超敏C-反应蛋白(hs-CRP)水平的变化,探讨PCI术后再狭窄的发生机制。方法置入支架的冠心病稳定型心绞痛患者83例入选本研究,男59例,女24例,年龄(57±9)岁,DES组43例,BMS组40例。另选同期住院行冠脉造影检查显示冠状动脉不同程度狭窄,而未行PCI的冠心病患者35例为对照组,男30例,女5例,年龄(59±11)岁。分别于术前和术后48、72 h、2 w和1个月后取静脉血,测定血浆hs-CRP水平,术前三组患者临床特征及冠脉造影显示的病变特征相似具有可比性。结果术后48、72 h DES组和BMS组患者较单纯进行冠脉造影的冠心病患者血浆hs-CRP水平显著升高〔分别为(8.34±2.78)、(15.11±3.37)vs(4.51±2.97)mg/L,P<0.01;(8.98±3.56)、(13.63±4.28)vs(3.82±2.65)mg/L,P<0.01〕;同时,DES组血浆hs-CRP水平较BMS组显著降低〔分别为(8.34±2.78)vs(15.11±3.37)mg/L,P<0.01;(8.98±3.56)vs(13.63±4.28)mg/L,P<0.01〕。结论 PCI术后可显著升高血浆hs-CRP水平,但DES与BMS相比,可明显降低血浆hs-CRP水平,表明DES可明显抑制PCI术后诱发的急性炎症反应,有降低再狭窄率的可能。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2012年第16期3376-3378,共3页 Chinese Journal of Gerontology
  • 相关文献

参考文献2

二级参考文献9

  • 1Prevention of cardiovascular events and death with Pravastatin in patients with coronary heart disease and a broad rang of initial cholesterol levels. The Long-term Intervention with Pravastatin in Ischemic Disease (LIPID) Study Group. N Engl J Med, 1998,339: 1349-1357.
  • 2Serruys PW, de Feyter P, Macaya C, et al. Fluvastatin for prevention of cardiac events following successful first percutaneous coronary intervention: a randomized controlled trial.JAMA, 2002 ,287:3215-3222.
  • 3Ruygrok PN, de Jaegere PT, van Domburg RT, et al. Clinical outcome 10 years after attempted percutaneous transluminal coronary angioplasty in 856 patients. J Am Coll Cardiol, 1996,27: 1669-1677.
  • 4Wilson SH, Berger PB, Mathew V, et al. Immediate and late outcomes after direct stent implantation without ballon predilation. J Am Coll Cardiol, 2000, 35: 937-943.
  • 5Ravkilde J, Nissen H, Mickley H, et al. Cardiac troponin T and CK-MB mass release after visually successful percutaneous transluminal coronary angioplasty in stable angina pectoris. Am Heart J, 1994,127: 13-20.
  • 6Harrington RA. Cardiac enzyme elevation after percutaneous coronary intervention:myonecrosis, the coronary microcirculation and mortality. J Am Coll Cardiol, 2000,35: 1142-1144.
  • 7Serruys PW, Foley DP, Jackson G, et al.A randomized placebo-controlled trial of fluvastatin for prevention of restenosis after successful coronary ballon angioplasty: final results of the fluvastatin angiographic restenosis (FLARE) trial. Eur Heart J, 1999,20: 58-69.
  • 8Mulder HJ, Bal ET, Jukema JW, et al. Pravastatin reduces restenosis two years after percutaneous transluminal coronary angioplasty (REGRESS trial). Am J Cardiol, 2000,86: 742-746.
  • 9陈学军,李建军,夏泠,王晶,李庚山.辛伐他汀对C反应蛋白和脂多糖诱导的单核细胞合成白细胞介素6的影响[J].中国动脉硬化杂志,2003,11(2):139-142. 被引量:37

共引文献42

同被引文献25

  • 1潘广杰,娄书花,薛书峰,赵建华,金军,马惠芳,田利平.血清C反应蛋白对冠状动脉临界病变患者的临床预后价值[J].中国心血管病研究,2007,5(4):276-277. 被引量:8
  • 2中华医学会心血管分会,中华心血管病杂志编辑委员会.经皮冠状动脉介入治疗指南.中华心血管病杂志,2002,30:707-718.
  • 3Mauri L,Silbaugh TS,Wolf RE,et al.Long-term clinical outcomes after drug-eluting and bare-metal stenting in Massachusetts.Circulation,2008,118:1817-1827.
  • 4Lee JY,Park DW,Kim YH,et al.Incidence,predictors,treatment,and long-term prognosis of patients with restenoeis after drug-eluting stent implantation for unprotected left main coronary artery disease.J Am Col] Cardiol,2011,58:1349-1358.
  • 5Nebeker JR,Virmani R,Bennett CL,et al.Hypersensitivity cases associated with drug-eluting coronary stents:a review of available cases from the Research on Adverse Drug Events and Reports (RADAR) project.J Am Coll Cardiol,2006,47:175-181.
  • 6Li JJ,Ren Y,Chen K J,et al.Impact of C-reactive protein on in-stent restenosis:a meta-analysis.Tex Heart Inst J,2010,37:49-57.
  • 7梁卓,姚天明,韩雅玲,等.冠心舒通胶囊对大鼠心肌缺血再糟注损伤的保护作用.2012中国心脏大会论文汇编.
  • 8Dietz U,Rupprecht HJ,Ekinci O,et al.Angiographic analysis of immediate and longterm results of PTCA vs PTCA in complex lesions (COBRA Study).Catheter Cardiovasc Interv,2001,53:359-367.
  • 9Blum A,Schneider DJ,Sobel BE,et al.Endothelial dysfunction and inflammation after percutaneous coronary intervention.Am J Cardiol,2004,94:1420-1423.
  • 10Li JJ,Fang CH,Jiang H,et al.Increased C-reactive protein level after renal stent implantation in patients with atherosclerotic renal stenosis.Angiology,2004,55:479-484.

引证文献2

二级引证文献11

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部