摘要
目的探讨肝硬化患者血小板参数、血液流变学和凝血功能指标的临床价值。方法对76例肝硬化患者和80名正常对照组的血浆凝血酶原时间、活化部分凝血活酶时间、凝血酶时间、纤维蛋白原进行检测，测定两组人群血流变参数及血小板参数。结果肝硬化患者组凝血酶原时间、活化部分凝血活酶时间、凝血酶时间均高于正常对照组，而纤维蛋白原低于正常对照组，两者之间差异有统计学意义（P〈0．05）；血小板参数中血小板计数和血小板压积低于正常对照组，血小板分布宽度和平均血小板体积高于正常对照组，两者之间差异有统计学意义（P〈0．05）；血流变参数中全血黏度、血浆黏度、红细胞压积均低于正常对照组。结论常规检测血小板参数、血液流变学和凝血功能指标，有助于临床判定肝硬化损害程度及判断预后。
Objective To explore the clinical significance of the platelet and hemorheology and coagulation parameters in liver cirrhosis.Methods We determined the levels of PT, APTT, TT, FIB and the platelet parameters and hemorheology in 76 patients diagnosed as liver cirrhosis and 80 normal controls. Results The PT, APTT, TT, PDW, MPV in liver cirrhosis group was obviously higher than normal controls,but FIB,PLT, PCT, HCT, whole blood and plasma viscosity were obviously lower than normal controls（P 〈 0.05）. Conclusions Measurement of the four platelet and hemorheology and coagulation parameters help to determine the loss of liver function and the prognosis in liver cirrhosis.
出处
《中国血液流变学杂志》
CAS
2012年第2期303-305,347,共4页
Chinese Journal of Hemorheology
关键词
肝硬化
凝血功能
血小板参数
血液流变性
liver cirrhosis
coagulation
platelet parameters
hemorheologic characteristics
