摘要
目的:观察榄香烯注射液与化疗联合治疗晚期肺癌的疗效,并观察其对凝血功能的影响。方法:将51例晚期肺癌患者分为化疗组25例和联合组26例,分别治疗6周,观察肿瘤客观缓解率、不良反应及凝血功能。结果:化疗组肿瘤缓解率和疾病控制率分别为25.0%及76.0%,联合组为26.9%和80.8%,联合组较化疗组有升高趋势但无统计学差异;两组不良反应和KPS评分无统计学差异;联合组治疗后较治疗前纤维蛋白原(FIB)及血小板(PLT)水平降低(P<0.05),而凝血酶原时间(PT)、国际标准化比值(INR)、凝血酶原活动度(PTA)、D-二聚体(D-D)和部分活化凝血活酶时间(APTT)改变不明显。结论:榄香烯注射液与化疗联合治疗晚期肺癌可通过降低FIB及PLT水平减轻患者血液的高凝状态,同时可能提高肿瘤缓解率和疾病控制率,二者联合使用具有一定协同作用。
Objective:To observe the effects of elemene injection on anti-tumor action and coagulation function in patients with advanced lung cancer.Methods:51 Patients with advanced lung cancer were divided into two groups:chemotherapy group was given chemotherapeutic drug only,and combination group was given both chemotherapeutic drug and elemene injection,each group was given the corresponding treatmet respectively for 6 weeks,the objective remission rate,adverse reaction and coagulation function were observed.Results:The objective remission rate and tumor control rate of chemotherapy group were 25.0% and 76.0%,while combination group was 26.9% and 80.8%,the latter was enhanced in the trend but no statistically significant difterence.Adverse reaction and Karnofsky performance score showed no difference between the two groups.The level of fibrinogen(FIB) and platelet(PLT) was lowered in combination group after treatment(P<0.05),while prothrombin time(PT),international normalized ratio(INR),prothrombin activity(PTA),D-dimer(D-D) and activated partial thromboplastic time(APTT) were not altered.Conclusion:Elemene injection combined with chemotherapy can reduce hypercoagulabale state and enhance objective remission rate and tumor control rate in patients with advanced lung cancer,injection has synergistic effect with chemotherapy.
出处
《中国中医药科技》
CAS
2012年第4期297-298,311,共3页
Chinese Journal of Traditional Medical Science and Technology
