摘要
目的评价我国牙科治疗用甲哌卡因和利多卡因用于口腔局部麻醉的效果。方法以万方数据知识服务平台、中国知网数据出版平台、维普资讯作为已发表国内文献的主要来源;检索时间：2011年7月18日。收集1990～2011年公开发表的有关甲哌卡因和利多卡因应用于口腔局部麻醉效果比较的中文文献。结果筛选出符合纳入标准的前瞻性随机对照试验13项（2320例）。甲哌卡因组的麻醉起效时间比利多卡因组缩短,麻醉持续时间较利多卡因组延长,但两项指标的差异均没有显著性（WMD=-7.60,95%CI：-23.98-8.78,P〉0.05;WMD=10.85,95%CI：-8.75-30.46,P〉0.05）。而两组的完全麻醉率差异有显著性（RR=1.48,95%CI：1.15-1.90,P〈0.05）,甲哌卡因的完全麻醉率为利多卡因的1.48倍,明显优于利多卡因。结论甲哌卡因的麻醉起效时间和麻醉持续时间与利多卡因相似,但完全麻醉率优于利多卡因,作为口腔科的局部麻醉用药具有一定优势。
【Objective】 To evaluate the local anesthetic effect of mepivacaine hydrochloride and lidocaine in dentist patients.【Methods】 Publications on the anesthetic effect of mepivacaine hydrochloride and lidocaine in dentist patients were collected,the data on the onset time of anesthesia,anesthesia duration,and rate of complete anesthesia were meta-analyzed using fixed effect model and random effect model.【Results】 Thirteen studies including 2 320 patients entered this study.The differences in the onset time of anesthesia（WMD=-7.60,95% CI：-23.98～8.78,P〈 0.05） and anesthesia duration（WMD=10.85,95% CI：-8.75～30.46,P〈 0.05） between the mepivacaine hydrochloride group and lidocaine group were not evident,but the difference in rate of complete anesthesia（RR=1.48,95% CI： 1.15～1.90,P〈 0.05） was evident,the rate of complete anesthesia was significantly higher in mepivacaine hydrochloride group than lidocaine group.【Conclusion】 The onset time of anesthesia and anesthesia duration were similar in mepivacaine hydrochloride group and lidocaine group,but the rate of complete anesthesia in mepivacaine hydrochloride group was higher than that in lidocaine group.As a dental anesthesia agent,mepivacaine hydrochloride has some advantages.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2012年第19期80-83,共4页
China Journal of Modern Medicine
关键词
甲哌卡因
利多卡因
口腔
局部麻醉
META分析
mepivacaine hydrochloride
lidocaine
dentistry
local anesthesia
Meta-analysis
