摘要
目的探讨睡眠呼吸暂停低通气综合征（OSAHS）对肾小管功能的影响。方法选择OSAHS患者35例和对照组30例，检测受试者尿视黄醇蛋白（uRBP）、尿β2-微球蛋白（uβ2-MG）和尿N-乙酰-β-D-氨基葡萄糖苷酶酶（uNAG），同时检测OSAHS患者的最低血氧饱和度（LSaO2）、血氧饱和度低于90％累积时间占睡眠时间（人睡到清晨觉醒前时间段）的百分比（DT90％）和睡眠呼吸紊乱指数（AHI），观察不同程度OSAHS对肾小管功能的影响。结果（1）轻、中度OSAHS组患者uNAG、uβ2-MG和uRBP的水平与对照组比较差异无统计学意义（P〉0．05）；（2）重度OSAHS组患者的uNAG、uRBP、uβ2-MG水平明显高于对照组，也明显高于轻、中度组（P〈0．05）。结论重度OSAHS患者存在。肾小管损伤，严重低氧血症可能是肾小管损伤的主要原因之一。
Objective To investigate the influence of obstructive sleep apnea-hypopnea syn- drome（OSAHS） on renal tubular function. Methods Thirty five OSAHS patients and 30 healthy adults were recruited. Polysomnography was used to diagnose and evaluate the severity of OSAHS. The urinary retinol binding protein （RBP） , β2 -microglobulin （ β2 -MG） , and N-acetyl- β -glucosaminidase （ uNAG ） were determined. Results （ 1 ） Compared with those in control group, there were no significant difference in uNAG, uβ2-MG, and uRBP levels in mild and moderate OSAHS groups （P 〉 0.05 ）. （2） The uNAG, uβ2- MG, and uRBP levels in severe OSAHS group were significantly higher than those in control group （P 〈 0.05 ）. Conclusion Severe OSAHS may have detrimental effect on renal tubular function. It is important to give a treatment and management on severe OSAHS for protecting renal tubular function.
出处
《临床内科杂志》
CAS
2012年第7期481-483,共3页
Journal of Clinical Internal Medicine
