摘要
Both embryonic and adult neurogenesis involves the self-renewal/proliferation, survival, migration and lineage differentiation of neural stem/progenitor cells. Such dynamic process is tightly regulated by intrinsic and extrinsic factors and complex signaling pathways. Misregulated neurogenesis contributes much to a large range of neurodevelopmental defects and neurodegenerative diseases. The signaling of NFKB regulates many genes important in inflammation, immunity, cell survival and neural plasticity. During neurogenesis, NFKB signaling mediates the effect of numerous niche factors such as cytokines, chemokines, growth factors, extracellular matrix molecules, but also cross- talks with other signaling pathways such as Notch, Shh, Wnt/l]-catenin. This review summarizes current progress on the NFttB signaling in all aspects of neurogenesis, focusing on the novel role of NFKB signaling in initiating early neural differentiation of neural stem cells and embryonic stem ceils.
Both embryonic and adult neurogenesis involves the self-renewal/proliferation, survival, migration and lineage differentiation of neural stem/progenitor cells. Such dynamic process is tightly regulated by intrinsic and extrinsic factors and complex signaling pathways. Misregulated neurogenesis contributes much to a large range of neurodevelopmental defects and neurodegenerative diseases. The signaling of NFKB regulates many genes important in inflammation, immunity, cell survival and neural plasticity. During neurogenesis, NFKB signaling mediates the effect of numerous niche factors such as cytokines, chemokines, growth factors, extracellular matrix molecules, but also cross- talks with other signaling pathways such as Notch, Shh, Wnt/l]-catenin. This review summarizes current progress on the NFttB signaling in all aspects of neurogenesis, focusing on the novel role of NFKB signaling in initiating early neural differentiation of neural stem cells and embryonic stem ceils.
