摘要
目的深入了解侵袭性垂体腺瘤的生物学特性 ,提高其诊断、治疗水平。 方法对 5 4例患者 (非侵袭性垂体腺瘤组 31例 ,侵袭性垂体腺瘤组 2 3例 )的临床、病理、细胞增殖动力学三方面资料作差异显著性检验及相关性分析。 结果在临床方面 ,两组在病程、肿瘤大小、肿瘤组织坏死、卒中、囊变发生率、手术全切除率、术后复发率等方面有显著差异 (P <0 .0 5 )。病理学研究 ,两组在微血管定量方面有显著差异 (P <0 .0 5 )。肿瘤细胞的增殖指数 (PCNA指数和Ki- 6 7指数 ) ,侵袭性腺瘤显著大于非侵袭性腺瘤 (P <0 .0 1)。 结论侵袭性垂体腺瘤进展快 ,多为大腺瘤 ,肿瘤组织坏死、囊变、卒中发生率高 ,手术全切除率低 ,术后易复发 ,肿瘤血供较为丰富 ,肿瘤细胞增殖较快。
Objective To find out the biological characteristics of invasive pituitary adenomas. Methods 54 patients (23 invasive pituitary adenomas, 31 non-invasive tumors) were investigated clinically pathologically and cell-kinetically. Results Significant clinical difference existed between two groups in interval time between symptom appearance and admission, tumor size, the incidence of apoplexy and cystic components, complete surgical removal and postoperative recurrence(P<0.05). In pathological findings, it was found that invasive adenomas had a higher micro-vascular density. And research on cell kinetics found that invasive pituitary adenoma had a higher proliferating rate.Conclusion Invasive pituitary adenoma was larger and had a fast clinical progress, a high incidence of necrosis, cystic components and apoplexy, a low rate of complete tumor removal and a high rate of postoperative recurrence. Tumor blood supply was more sufficient and tumor cell proliferating rate was higher.
出处
《上海第二医科大学学报》
CSCD
2000年第4期322-324,共3页
Acta Universitatis Medicinalis Secondae Shanghai
