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三联治疗对肾性骨病患者的疗效及对血清中IL-6和IL-12含量的影响 被引量:9

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摘要 目的观察三联治疗(低钙透析液、盐酸司维拉姆、骨化三醇冲击)对肾性骨病患者的疗效,关注其对血清中白细胞介素(IL)-6和IL-12的调节作用,探讨其临床意义。方法收集44例肾性骨病患者,分为对照组20例,给予氢氧化铝凝胶10 mL 3次/d餐中服,待钙磷乘积小于60后改为碳酸钙0.6 g,3次/d餐中服,骨化三醇2μg,隔天1次;观察组24例,使用低钙透析液,盐酸司维拉姆800 mg,3次/d餐中服,同时使用骨化三醇冲击。观察两组的疗效及血清中IL-6和IL-12含量的变化。结果观察组疗效明显优于对照组,观察组和对照组治疗后血清中IL-6和IL-12的含量均明显下降,但观察组的下降值明显高于对照组。结论应用三联治疗对肾性骨病患者的治疗效果明显,并能明显下调血清中的IL-6和IL-12含量。
作者 叶晴 张竞葳
出处 《广东医学》 CAS CSCD 北大核心 2012年第15期2248-2249,共2页 Guangdong Medical Journal
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  • 1<活性维生素D的合理应用>专家协作组.活性维生素D在慢性肾脏病继发性甲旁亢中合理应用的专家共识(修订版)[J].中华肾脏病杂志,2005,21(11):698-699. 被引量:97
  • 2郑法雷,袁群生.肾性骨病诊治中的新问题及有关进展[J].实用医院临床杂志,2006,3(4):2-5. 被引量:18
  • 3黎磊石,刘志红主编.中国肾脏病学[M].北京:人民军医出版社,2008,1328-1338
  • 4Lai KN,Ho K,Cheang RC,et al.Effect of low mole-cular weight heparin on bone metabolism and hyperli-pidemia in patienla on maintenance hemodialysis[J].Int J Artif Organs,2001,24:447-455.
  • 5Lein NW,Hulberg-shearon TE,Strawderman RL,et al.Which causes of death are related to Hyperpho-sphatemin in hemodialyiss patients[J].J Am Soc Nephrol,1998,9:217.
  • 6Stillion JR, Ritt M. Renal secondary, hyperparathyroidism. Compend contin Educ Vet, 2009,31 (6) :E1 - E11.
  • 7Slatopolsky E, Dusso A, Brown AJ. The role of phosphorus in the development of secondary hyperparathyroidism and parathyroid cell proliferation in chronic renal failure. Am J Med Sci, 1999,317 ( 6 ) : 370 - 376.
  • 8Block GA, Klassen PS, Lazarus JM, et al. Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. J Am Soc Nephrol, 2004,15 ( 8 ) : 2208 - 2218.
  • 9Slatopolsky E, Finch J, Denda M. et al. Phosphorus restrietion prevents parathyroid gland growth. High phosphonts directly stimulares PTH secretion in vitro. J Clin Invest, 1996,97 ( 11 ) : 2534-2540.
  • 10Yi H, Fukagawa M, Yamato H, et al. Prevention of enhanced parathy- roid hormone secretion, synthesis and hyperplasia by mild dietary phosphorus restriction in early chronic renal failure in rats : possible direct role of phosphorus. Nephron, 1995,70 ( 2 ) :242 - 248.

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  • 1牛新,吕放光.骨化三醇治疗肾性骨病疗效观察——附35例报告[J].新医学,2006,37(9):596-598. 被引量:4
  • 2刘淑萍,吕瑞芳,金丽霞.鲑降钙素治疗骨质疏松症腰背痛的观察及护理[J].现代中西医结合杂志,2006,15(19):2710-2710. 被引量:5
  • 3牛新,吕放光.骨化三醇防治透析性骨病临床观察[J].现代预防医学,2007,34(4):891-892. 被引量:8
  • 4王海燕.肾脏病学[M].3版.北京:人民卫生出版社,2008:8262.
  • 5Wataru Obara, Ryuichim konda.Prognostic significance of vitaminD Receptor and Retinoid X Receptor Expression in Renal cellcareinom[J].Urology, 2007 , 24 (178):1497-1503.
  • 6邓朝蓬,罗福漳,李丽波,等盐酸司维拉姆对维持性血液透析患者微炎症状态的影响[J].医学信息,2012,25(10):107.
  • 7Hernandez JD, Wesseling K, Salusky IB.Role of parathyroid hormone and therapy with active vitamin D sterols in renal osteodystrophy. Semin Dial, 2005, 18(4):290.
  • 8Meng Y, Zhang H, Li Y, et al. Effects of unfractionated heparin on renal osteodystrophy and vascular calcification in chronic kidney dis- ease rats[ J]. Bone,2014,58:168 -176.
  • 9Aoki C, Uto K, Honda K, et al. Advanced glycation end products suppress lysyl oxidase and induce bone collagen degradation in a rat model of renal osteodystrophy[ J]. Lab Invest ,2013,93 ( 11 ) : 1170.
  • 10Malluche HH, Mawad HW, Monier-Faugere MC. Renal osteodystm- phy in the first decade of the new millennium : analysis of 630 bone biopsies in black and white patients [ J ]. J Bone Miner Res,2011,26 (6) :1368 - 1376.

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