摘要
目的探讨血浆置换在治疗溶血尿毒综合征（hemolyticuremicsyndrome，HUS）中的意义。方法对本院2008年1月至2010年12月收治的16例HUS患儿进行血浆置换治疗；以新鲜冰冻血浆作置换液，治疗时间每次2—3h。结果16例患儿经血浆置换治疗均存活，无明显并发症出现。全部患儿首次治疗后病情明显缓解；12—72h，黄疸消失，血肌酐[（385．0±189．4）μmol／LVS（100．0±19．3）μmol/L]、乳酸脱氢酶明显下降[（799．3±289．8）U／LVS（300．0±100．4）U／L]，血小板计数[（45．0±18．8）×109／LVS（120．0±20．0）×109／L]、血红蛋白回升[（59．3±15．3）g/L VS（120．0±18．3）g/L]，差异均有统计学意义（P〈0．05）。出院时15例患儿症状消失，14例实验室检查正常。住院时间为15～57d。结论血浆置换可以有效缓解病情，清除血浆致病物质，及时阻断HUS的病理过程，补充血浆中有效成分。推荐血浆置换作为治疗HUS的首选治疗方案。
Objective To investigate the significance of plasma exchange （PE） treatment on children with hemolytic uremic syndrome （HUS）. Methods From Jan 2008 to Dec 2010,16 patients diagnosed with HUS were included in this study, and PE was carried out on them. Frozen plasma was taken as replacement flu- id,and the treatment time was 2 to 3 hours per time. Results All the 16 patients after PE treatment were sur- vived without any apparent complications. The condition obviously alleviated after initial treatment. In 12 to 72 hours ,the ictems disappeared, serum creatinine [ （ 385.0 ±189.4 ） μmol/L vs （ 100. 0 ± 19. 3 ）μmol/L ] and lactate dehydrogenase [ （ 799. 3 ± 289. 8 ） U/L vs （ 300. 0 ± 100. 4 ） U/L ] declined obviously （ P 〈 0. 05 ） and platelet count [ （45.0 ± 18. 8） × 109/L vs （ 120. 0 ± 20. 0） × 109/L] , hemoglobin [ （59. 3± 15. 3 ） g/L vs （ 120. 0 ± 18.3 ） g/L] fised（ P 〈 0. 05 ）. In the end, symptoms disappeared in 15 patients, laboratory examination returned to normal in 14 cases. Hospitalization time was 15 to 57 days. Conclusion PE can effectively relieve the illness and remove plasma pathogenic substances ,block the pathological process of HUS and supply useful ingredients. Recommend PE as the first option in the treatment of HUS.
出处
《中国小儿急救医学》
CAS
2012年第4期390-392,共3页
Chinese Pediatric Emergency Medicine
关键词
血浆置换
溶血尿毒综合征
儿童
Plasma exchange
Hemolytic uremic syndrome
Children
