摘要
目的:我国高血压患病率呈持续上升态势,高血压知晓率、治疗率及控制率均较低,本研究旨在观察依那普利与氢氯噻嗪联合应用对初始治疗失败的高血压患者的疗效。方法:纳入156例高血压患者,予改善生活方式及药物治疗,氢氯噻嗪25mg/d联合依那普利5～10 mg/d,共治疗8周,观察血压达标情况。结果:两药联合治疗患者依从性良好;治疗后患者血压显著改善,收缩压、舒张压均下降;单纯高血压患者收缩压、舒张压均达标比率高达59.3%,总体达标率达73.2%;合并糖尿病患者收缩压、舒张压均达标比率达40.0%,总体达标率达53.6%。结论:依那普利与氢氯噻嗪联合应用对初始治疗失败的高血压患者的疗效肯定,值得临床推广应用。
Objective ：The prevalence of hypertension has sustained an upward trend, but the awareness,treatment, and control rates of hypertension are still low. The purpose of this study was to investigate the efficacy of enalapril combined, with hydrochlorothiazide for the treatment of uncontrolled hypertensive patients. Methods： One hundred and fifty-six patients were recruited with uncontrolled hyperten- tion and were given drug treatment （ enalapril 5.0 - 10. 0 mg/d and hydrochlorothiazide 25.0 rag/d） for eight weeks. The study then in- vestigated the control rate of blood pressure of the uncontrolled hypertensive patients. Results： Compliance with the combination of enala- pril and hydrochlorothiazide was good. After treatment, the blood pressure of the uncontrolled hypertensive patients improved significantly, and both the systolic pressure and diastolic pressure decreased. The control rate of both the systolic pressure and diastolic pressure of non- diabetic hypertensive patients was 59. 3% ,and the overall control rate was 73.2% ,while those of the diabetic hypertensive patients were 40. 0% and 53.6% ,respectively. Conclusion： The therapy of enalapril combined with hydrochlorothiazide has positive effects for uncon- trolled hypertensive patients and is worthy of clinical application.
出处
《川北医学院学报》
CAS
2012年第4期380-383,共4页
Journal of North Sichuan Medical College
关键词
高血压
依那普利
氢氯噻嗪
血压达标
Hypertension
Enalapril
Hydrochlorothiazide
Controlling blood pressure
