摘要
目的比较血液透析、血液透析滤过、血液灌流3种不同血液净化方式对终末期肾病患者血脂代谢的影响。方法将36例尿毒症患者分为3组,血液透析组(HD组)、血液透析滤过组(HDF组)、血液灌流组(HP组)各12例,分别进行不同血液净化治疗并观察6个月,观察各组患者在治疗前及治疗6个月后血脂TC、TG、HDL-C、LDL-C的变化情况。结果血液净化开始时3组患者血脂水平比较差异无统计学意义,治疗6个月后HD组及HDF组血脂水平较治疗前差异无统计学意义,HP组血脂TC、TG、HDL-C、LDL-C均较治疗前显著下降(P<0.05)。结论血液透析、血液透析滤过对尿毒症患者血脂紊乱无改善作用,而血液灌流可改善尿毒症患者血脂代谢。
Objective To investigate the influence of different blood purifies on the serum lipid levels in the patients with chronic renal failure. Methods 36 patients with end stage renal disease were treated with maintenance renal replacement therapy of HD（n =12） ,HDF（n=12）or HP（n=12）for 6 months. Serum total cholesterol（TC）,triglycerides（TG）,low-density lipoprotein（LDL）and high density lipoprotein（HDL） were measured prior to treatment and 6 months after treatment. Results At the beginning of the treatment, no significant differences in serum lipids were found among the 3 groups. In patients treated with HD or HDF, no signifi- cant alterations in serum lipids were found before and after the treatment, however,in those treated with HP,TC, TG, LDL, HDL decreased remarkable after the treatment（P〈0.05）. Conclusion The hemoperfusion is significantly better than the HD, HDF in the improvement of derangement of lipid metobolism in uremic patients.
出处
《重庆医学》
CAS
CSCD
北大核心
2012年第23期2381-2382,共2页
Chongqing medicine
