摘要
目的:探讨血清鳞状细胞癌抗原(squamous cell carcinoma antigen,SCCAg)对宫颈鳞癌诊断及术后疗效的评估价值。方法:采用酶联免疫吸附实验(ELISA)检测血清中SCCAg的水平。研究组:宫颈鳞癌组(IA2-IIA期)50例;对照组1:宫颈上皮内瘤变组(CIN组)25例;对照组2:慢性宫颈炎组25例。研究组在术前、术后分别检测血清SCCAg浓度。对照组仅检测治疗前血清SCCAg浓度。应用ROC曲线等方法分析血清SCCAg水平与宫颈鳞癌临床病理特征、手术疗效的关系。结果:宫颈鳞癌组术前血清SCCAg水平明显高于对照组,差异具有统计学意义(P<0.01)。对照组间差异无统计学意义(P=0.432)。宫颈鳞癌组术后在1年内没有复发的情况下动态检测血清SCCAg水平呈进行性下降,差异具有统计学意义(P<0.001)。宫颈鳞癌组术前血清SCCAg水平与临床分期、肿瘤体积、分化程度、间质浸润、盆腔淋巴结转移等有关(P<0.001)。血清SCCAg诊断宫颈鳞癌及预测盆腔淋巴转移的临界值分别为0.94 ng/ml和3.15 ng/ml,ROC曲线下面积分别为0.904、0.797。结论 :血清SCCAg检测对宫颈鳞癌具有较高的诊断价值,也是评价宫颈鳞癌术后疗效及预测盆腔淋巴结转移的重要指标。
Objective： To explore the appraisal value of serum squamous cell carcinoma antigen （SCCAg） for diagnosis and surgical effect of cervical squamous cell carcinoma by ROC cuIve. Methods： ELISA was used to detect the serum levels of SCCAg in 50 cases in study group （cervical squamous cell carcinoma of stage IA2 - II A）, 25 cases in control one group （cervical intraepithelial neoplasia）, and 25 cases in control two group （chronic cervicitis） . Serum SCCAg levels in study group were detected before and after surgery, respectively, while in control group, the levels of serum SCCAg before treatment were detected. ROC curve was used to analyze the relationship between serum SCCAg level and clinicopathological characteristics, surgical effect of cervical squamous cell carcinoma. Results： Before surgery, the serum SCCAg level in study group was statistically significandy higher than those in control group （P 〈 0. 01 ） . But there was no statistically significant difference between control one group and control two group （P = 0. 432） . Progressive decrease of serum SCCAg level was showed by dynamic detection on the condition of no recurrence within one year after surgery in study group, there was statistically significant difference （P 〈 0. 001 ） . The preoperative level of serum SCCAg in study group was correlated with clinical stages, tumor volume, degrees of dif- ferentiation, interstitial invasion, and lymph node metastasis in pelvic cavity （P 〈 0. 001 ） . The threshold values of serum SCCAg for diagnosis of cervical squamous cell carcinoma and prediction of lymph node metastasis in pelvic cavity were 0. 94 ng/ml and 3, 15 ng/ml, respectively ; the areas under ROC curve were 0. 904 and 0. 797, respectively. Conclusion： Serum SCCAg detection has high value for diagnosis of cervical squamous cell carcinoma, which also is one of important indexes to evaluate surgical effect of cervical squamous cell carcinoma and predict lymph node metastasis in pelvic cavity.
出处
《中国妇幼保健》
CAS
北大核心
2012年第25期3875-3878,共4页
Maternal and Child Health Care of China
基金
贵州省科技厅基金课题〔No:黔科合J字(2008)2197〕
关键词
宫颈鳞癌
鳞状细胞癌抗原
诊断
手术疗效
ROC曲线
Cervical squamous cell carcinoma
Squamous cell carcinoma antigen
Diagnosis
Surgical effect
ROC curve
