摘要
动物实验表明,短期或长期高碘摄入会对机体产生一定的毒性,包括发育毒性、遗传毒性和致畸性等。目前世界各国家及组织对于碘的推荐摄入量(reference nutrition intake,RNI)和可耐受最高摄入量(tolerable upper intake level,UL)的制定一般是基于一些的人体实验研究和人群调查,但由于地理环境及人种差异等原因,所得数据并不统一。由于参照的研究数据不同,各国对不同人群设定的碘安全摄入量参照标准也不尽相同。鉴于此,分析了国际上主要的国家及国际组织制订标准的过程与依据,概述了我国相关标准的制订过程与依据以及目前的研究进展,明确了进一步探讨和研究更适合我国人群的碘的安全摄入量是当前和今后的工作重点之一,也是食盐加碘计划(universal salt iodization,USI)科学实施的重要保障。
Animal experiments have shown that it is poisonous to have excessive iodine intake for a short or long time. Besides, iodine has the developmental toxicity, genetic toxicity and teratogenicity. The establishment of RNI and UL of iodine from some countries and organizations were based on some human experiments and population studies, and for the different geographic environments and the racial difference, the values were different. The values and reasons of RNI and UL of several main countries and international orgnizations have been reviewed, as aresult, it will be an important work for us to further disscuss and study the safe intake levels of iodine which is more suitable for Chinese population nowadays and in the future, which is the important guarantee for the scientific implementation of USI.
出处
《生命科学》
CSCD
2012年第8期909-916,共8页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(3084006
30972465)
教育部高等学校博士学科点(博导类)
专项科研基金项目(20111202110014)
关键词
碘
推荐摄入量
可耐受最高摄入量
iodine
recommended nutrition intake
tolerable upper intake level
