摘要
目的评价戊巴比妥钠对大鼠复合肌肉动作电位（CMAP）的影响。方法成年SD大鼠10只，雌、雄各半，8周龄，体重240～260g。腹腔注射1％戊巴比妥钠40mg／kg，给药后8min时开始刺激坐骨神经，记录其所支配的腓肠肌的CMAP，刺激强度为0．50、0．55、0．60V，每个刺激强度重复3次（刺激间隔1S），波宽0．05ms，频率10Hz。每隔5min重复上述刺激1次，分别为T1、T2、T3、T4、T5、T6、T7、T8、T9、T10。结果与T1时比较，0．50、0．55、0．60V强度下L3-5时CMAP峰值降低，0．50V强度下L3-6时CMAP潜伏期延长，0．55、0．60V强度下T4、5时CMAP潜伏期延长（P〈0．05或0．01）。结论戊巴比妥钠可抑制大鼠CMAP。
Objective To investigate the effects of pentobarbital sodium on compound muscle action potentials （CMAPs） in rats. Methods Ten adult Sprague-Dawley rats （5 males, 5 females）, aged 8 weeks, weighing 240-260 g, were anesthetized with intraperitoneal 1% pentobarbital sodium 40 mg/kg. The sciatic nerve was stimulated （intensity 0.50, 0.55 and 0.60 V, wave length 0.05 ms, frequency 10 Hz） starting from 8 min after administration. Each intensity was repeated three times at 1 s interval. The stimulation mentioned above was repeated every 5 min. CMAPs from the gastrocnemius muscle were recorded starting from 8 min after administration （T,） and then were recorded every 5 min for 9 times （T2-10） . Results The peak value of CMAP was significantly decreased at T3.s when the intensity was 0.50, 0. 55 and 0.60 V, and CMAP latency was significantly prolonged at T3-6 when the intensity was 0.50 V, and at T4.5 when the intensity was 0.55 and 0.60 V as compared with those at T1 （ P 〈 0.05 or 0. 01 ）. Conclusion Pentobarbital sodium can inhibit CMAPs in rats.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
2012年第7期814-816,共3页
Chinese Journal of Anesthesiology
基金
国家自然科学基金（30901404）
关键词
戊巴比妥
动作电位
肌电描记术
Pentobarbital
Action potentials
Electromyography
