摘要
目的:探讨正常乳腺组织、乳腺癌原发病灶及乳腺癌复发转移灶中阴阳因子-1(YY1)的表达及其临床意义。方法:采用免疫组织化学SP法检测56例乳腺癌原发病灶及其对应的复发后二次手术的乳腺癌转移灶,以及20例正常乳腺组织中YY1的表达情况,并分析其与ER、PR、c-erbB-2、Ki-67和p53等多个乳腺癌相关因子及临床病理参数的关系。结果:乳腺癌复发转移灶中,YY1的阳性表达率为78.6%(44/56),显著高于乳腺癌原发病灶的51.8%(29/56)及正常乳腺组织的25.0%(5/20),差异有统计学意义,P<0.05。YY1的表达与乳腺癌组织学分级、TNM分期、腋窝淋巴结转移及复发部位相关(P<0.05),而与患者的年龄、肿瘤大小无关,P>0.05;YY1的表达与ER表达呈负相关(P<0.05),与c-erbB-2和Ki-67表达呈正相关(P<0.05),而与PR和p53表达无明显的相关性,P>0.05。结论:YY1的高表达预示着肿瘤具有较高的侵袭性和转移性,YY1有望成为乳腺癌治疗的新靶点。
OBJECTIVE： Measuring the expression of YinYang-1 （YY1） in normal breast tissues, primary breast cancer lesions and metastasis lesions of breast cancer. To study the correlation of ER, PR, c-erbB-2, Ki-67, p53 and YY1 in order to investigate the role of YY1 in the metastasis of breast cancer. METHODS： The expression of YY1 was detected in primary breast cancer tissues, metastasis tissues from 56 breast cancer patients and normal breast tissues from 20 patients with benign breast diseases by immunohistochemical staining. Analyzing the expression of YY1 to clinical characteristics. RESULTS： The positive rate of YY1 in metastasis lesions of breast cancer was 78. 6% （44/56）, it was significantly higher than that in primary breast cancer lesions 51.8% （29/56）and normal breast tissues 25.0% （5/20, P〉0.05）. There was a positive correlation between breast cancer tissue grades, TNM, axillary lymph node metastasis,position of metastasis and the expression of YYI（P〉0.05） ,there was no correlation between age, the size of tumor and the expression of YY1 （P〉0.05）. YY1 had a negative correlation with ER（P〉0.05）, a positive correlation with c-erbB-2, Ki-67, and no correlation with PR, p53 （P〉0.05）. CONCLUSION： YY1 plays an important role in the development of breast cancer, promotes the metastasis of breast cancer and would become a new target point of breast cancer.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2012年第13期966-969,共4页
Chinese Journal of Cancer Prevention and Treatment
基金
国家自然科学基金(30970806)
教育部博士点基金(200802260011)
黑龙江省科技计划项目(WB08B03)
