摘要
目的:观察复方痤疮胶囊的药理学作用,为临床用药和进一步的开发研究提供理论依据。方法:用平板法37℃厌氧培养痤疮丙酸杆菌72 h,定量测定复方痤疮胶囊最低抑菌浓度,并观察其对二甲苯致炎剂所致小鼠耳廓肿胀的影响。结果:复方痤疮胶囊对痤疮丙酸杆菌的最低抑菌浓度分别为200 mg.ml-1;复方痤疮胶囊2.4 g.kg-1,1.2 g.kg-1能有效地降低二甲苯致炎剂所致小鼠耳廓的肿胀(P<0.01)。结论:复方痤疮胶囊有明显的抑菌、抗炎作用。
Objective： To study the phartnacodynamics of Fufang Cuoehuang capsules. Method： Propinibaeterium acnes were cultured in an anaerobic condition at 37℃ for 72 hours by plating method. Result： The minimum inhibitory concentration of Fufang Cuochuang capsules for propinibacterium acnes was 200 mg · ml- 1. Fufang Cuochuang capsules with the dose of 2.4 g ·kg-1 and 1.2 g · kg-1 could significantly inhibit the swelling of mouse ears induced by xylene （P 〈 0.01 ）. Conclusion： Fufang Cuoehuang capsules show obvious antibacterial and anti-inflammatory effects.
出处
《中国药师》
CAS
2012年第8期1098-1100,共3页
China Pharmacist
基金
2010年中央级公益性科研院所基本科研业务专项基金(编号:201006)
关键词
复方痤疮胶囊
痤疮丙酸杆菌
抗炎
抑菌
Fufang Cuoehuang capsules
Propinibacterium acnes
Anti-inflammatory action
Antibacterial effect
