摘要
目的探讨枳实破壁粉粒对小鼠小肠推进作用的影响及对小鼠的急性毒性作用。方法通过考察小鼠小肠炭末推进率,评价枳实破壁粉粒对小肠的推进作用;采用最大给药量法观察枳实破壁粉粒的毒性。结果临床等效剂量的枳实破壁粉粒对小鼠小肠推进有显著的促进作用,1/2临床等效的破壁粉粒对小鼠小肠的推进作用相当于常规饮片临床等效剂量的效果;未见枳实破壁粉粒对小鼠的急性毒性反应。结论枳实破壁粉粒具有促进小肠推进作用且无急性毒性作用。
Objective To study the effect of the wall-broken spore power of Aurantii Fructus Immaturus on the intestinal transit and acute toxicity test in mice.Methods The effect of the wall-broken spore power of Aurantii Fructus Immaturus on the intestinal transit was evaluated by the small intestinal carbon transit rate,which toxicity was detected by maximum dosage test.Results The clinical equivalent dose of the wall-broken spore power of Aurantii Fructus Immaturus showed a prominent promotion effect on intestinal transit.Half dose of the wall-broken spore power worked equally to its cut crude drugs.And no acute toxicity in mice occurred.Conclusion The wall-broken spore power of Aurantii Furctus Immaturus exhibits a beneficial effect on intestinal transit with no acute toxicity.
出处
《广东药学院学报》
CAS
2012年第4期435-437,共3页
Academic Journal of Guangdong College of Pharmacy
基金
广东省粤港关键领域重点突破招标项目(20080106-2)
广东省科技计划项目(2008B080101034)
中山市科技强企支撑计划项目(20092A113)
关键词
枳实
破壁粉粒
小肠推进作用
急性毒性
Aurantii Furctus Immaturus
wall-broken spore power
the effect on intestinal transit
acute toxicity
