摘要
目的研究药物洗脱支架(drug-eluting stent,DES)突起高度对药物释放动力学和血流动力学的影响,为DES的优化设计提供依据。方法采用计算流体动力学(computational fluid dynamics,CFD)方法,对血流动力学和药物释放动力学进行耦合分析,考虑3种不同突起高度支架,研究血管壁组织中药物含量和壁面切应力的分布。结果支架突起高度的增加将有利于药物的沉积,但将增加低切应力区长度。比较而言,血管壁中药物含量随着突起高度增加的幅度远小于低切应力区长度的增加。结论综合考虑药物浓度和壁面切应力两种因素,建议适当降低支架的突起高度,以便更有效地降低再狭窄产生的几率。
Objective To investigate effects from the protrusion height of drug-eluting stent（DES） on kinetics of drug release and hemodynamics,so as to provide references for the optimization of DES design.Methods Based on computational fluid dynamics（CFD）,coupling analysis on kinetics of drug release and hemodynamics was conducted by studying three stent models with different protrusion height to numerically investigate the distribution of drug concentration and wall shear stress.Results The increase in protrusion height of the stent was beneficial to the drug deposition;however,it could also increase the length in the low shear stress area.Comparatively,the increase percentage of drug concentration with the increasing protrusion height was remarkably less than that of the increasing length in low shear stress area.Conclusions By comprehensive consideration of both the drug concentration and wall shear stress,lower protrusion height is recommended for DES so as to effectively reduce the risk of restenosis.
出处
《医用生物力学》
EI
CAS
CSCD
北大核心
2012年第4期451-455,共5页
Journal of Medical Biomechanics
基金
国家自然科学基金资助项目(10872138)
关键词
药物洗脱支架
药物浓度
切应力
计算流体动力学
血流动力学
Drug-eluting stents
Drug concentration
Shear stress
Computational fluid dynamics（CFD）
Hemodynamics
