摘要
目的:通过蛭龙活血通瘀胶囊对急性脑梗塞治疗前后血清血管内皮生长因子(VEGF)、C反应蛋白(CRP)含量变化影响的研究,验证蛭龙活血通瘀胶囊对治疗急性脑梗塞的脑保护作用。方法:78例急性脑梗塞患者,随机均分A组(常规治疗组)、B组(常规治疗加蛭龙活血通瘀胶囊治疗)。对治疗前后神经功能缺损(ESS)、日常生活能力(ADL)评分和血清VEGF、CRP含量的变化进行比较分析。结果:A、B两组治疗后ESS、ADL比较有统计学意义(P<0.05);A、B两组血清VEGF、CRP含量在治疗7d后达高峰,但B组较A组值低(P<0.05),治疗后28d两组无统计学意义(P>0.05)。结论:蛭龙活血通瘀胶囊对急性脑梗塞有脑保护作用,同时检测急性脑梗塞患者血清中VEGF、CRP水平变化对了解疾病发展、指导用药具有重要的临床价值。
Objective： To study the changes of serum VEGF and CRP in acute cerebral infarction treated by Zhilonghuoxuetongyu capsule,and try to explore their roles in acute cerebral infarction.Methods： 78 patients with acute cerebral ischemia were randomly devided into A group（conventional therapy group）,B group（conventional therapy plus Zhilonghuoxuetongyu capsule therapy group）,and their neurologic impairment（ESS）,activity of daily living（ADL）,serum vascular endothelial growth factor（VEGF）,and C reactive protein（CRP） content were compared before and after treatment.Results： ESS and ADL had statistical significance between A and B group（P0.05）;serum VEGF and CRP arrived at the peak 7 day post-treatment,but in A group the serum between VEGF and CRP were lower than in B group.There was no statistical significance 28 day post-treatment（P0.05）.Conclusion： Zhilonghuoxuetongyu capsule can protect the brain from acute cerebral infarction,and the detection of serum VEGF and CRP is useful for understanding the progression of disease and guideing the clinical medication.
出处
《泸州医学院学报》
2012年第4期402-404,共3页
Journal of Luzhou Medical College
