摘要
目的:了解抗菌药引起的药品不良反应(ADR)的发生特点。方法:回顾性分析我院2007年12月～2010年12月临床科室自发呈报的268例抗菌药所致不良反应报告,对引起不良反应的药品、给药途径、临床表现、患者年龄、性别、不良反应史等方面进行统计分析。结果:268例抗菌药不良反应报告中中老年人比例最大,占59.70%;给药途径以静脉滴注为主,占78.36%;以头孢菌素类ADR比例最高,占53.73%;主要的不良反应为皮肤及附件损害,占47.76%。结论:应高度重视抗菌药不良反应,合理用药,避免或减少ADR的发生。
Objective ：To understand the features of ADRs induced by antimicrobial drugs in our hospital. Methods ：The reports of 268 cases of adverse reaction induced by antibiotics collected in December 2007 to December 2010 were retrospectively analyzed. The drug species, route of administration, clinical performance and patients＇ age, sex and history of adverse reactions were statistically analyzed. Results ：The proportion of the 268 cases of adverse drug reaction occurring to the elderly was the largest, accounting for 59.70% ; that of the route of administration by intravenous infusion, account- ing for 78.36% ; the proportion of ADR induced by cephalosporins was the highest, accounting for 53.73% ; and the major adverse reactions and accessories for the skin damage accounted for 47.76%. Conclusion： Great importance should be attached to the occurrence of adverse reactions of antibiotics and rational use of drugs to prevent or reduce the incidence of ADRs.
出处
《药物流行病学杂志》
CAS
2012年第7期325-327,337,共4页
Chinese Journal of Pharmacoepidemiology
关键词
抗菌药
药品不良反应
回顾性分析
Antibiotics
Adverse drug reactions
Retrospective analysis
