摘要
目的探讨吡拉西坦和甘露醇治疗颅内肿瘤术后颅内压增高的疗效及安全性。方法应用随机数字表法将2009年12月至2011年12月在天津市第五中心医院神经外科住院治疗的102例颅内肿瘤术后颅内压增高患者分为对照组(51例)和观察组(51例),对照组患者给予20%甘露醇进行治疗,观察组患者给予吡拉西坦注射液进行治疗,其他治疗措施相同,比较对照组与观察组患者临床疗效和不良反应发生情况。结果观察组患者的治疗总有效率(96.1%)明显高于对照组(84.3%),且对照组与观察组患者在不良反应发生率方面差异无统计学意义(P>0.05)。结论吡拉西坦注射液治疗颅内肿瘤术后颅内压增高疗效确切,能够代替甘露醇用于颅内肿瘤术后颅内压增高患者降颅压治疗,明显提高临床疗效,且不良反应少,值得进一步推广。
Objective To investigate the clinical efficacy and safety of patients with high intracra- nial pressure after intracranial tumor surgery to provide reference for a safe and effective treatment on it. Methods We collected clinical data of 102 cases of patients who were treated in the department of neuro- surgery in our hospital from December 2009 to December 2011. These patients were divided into the control group and observation group by using a random number table, patients in the control group was given 20% Mannitol, but patients in the observation group was given 20% Piracetam injection, the clinical efficacy and adverse reaction of patients in the control group and the observation group was evaluated. Results The total efficient rate was higher in the observation group than that in the control group （96. 1% vs 84. 3%, P 〈 0. 05 ） , adverse reaction of patients in the control group and the observation group has no difference （ P 〉 0.05）. Conclusions Piracetam injection in the treatment of intracranial tumor postoperative intracranial hypertension curative effect, and it is safe, reliable and worthy of clinical application.
出处
《中国肿瘤临床与康复》
2012年第4期359-360,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
吡拉西坦
甘露醇
颅内肿瘤
颅内压增高
Mannitol
Piracetam
Intracranial neoplasms
High intracranial pressure
