摘要
目的:通过联合测定冠心病患者血清胱抑素C(Cystatin C,CysC)和白介素-18(interleu-kin,IL-18)水平,探讨CysC和IL-18在冠心病病情评估中的意义。方法:应用全自动生化分析仪和酶联免疫吸附法(ELISA)测定58例冠心病患者血清CysC和IL-18水平,同时与40例正常对照组检测结果进行比较。结果:冠心病各组患者血清CysC和IL-18水平较对照组显著升高,差异有统计学意义(P<0.01);冠心病各组患者血清IL-18水平间相互比较,差异有统计学意义(P<0.01);血清CysC高水平组患者发生二次心血管事件的发病率明显高于低水平组(X2=4.392,P<0.05)。结论:联合测定冠心病各组患者血清CysC和IL-18水平,对冠心病的诊断、治疗及病情评估等方面具有较高的临床应用价值。
Objective： To investigate the significance of joint detection of serum levels CysC and IL-18 in patients with coronary artery disease.Method： The automatic biochemical analyzer and ELISA were used to detect the serum levels of CysC and IL-18 in 58 patients with coronary heart disease and the test results were comparing with 40 healthy controls.Result：The serum levels of CysC and IL-18 in 58 patients with coronary heart disease were significantly higher than those of healthy controls,the difference was statistically significant（P0.01）.The serum levels of IL-18 compared to each other,The difference was statistically significant（P0.01）.The incidence of cardiovascular events of the second in patients with high serum level of CysC was significantly higher than the low group（X2=4.392,P0.05）.Conclusion：Joint detection of serum levels CysC and IL-18 in patients with coronary artery disease has a higher value of clinical application for diagnosis,treatment and disease assessment.
出处
《河北医学》
CAS
2012年第11期1536-1538,共3页
Hebei Medicine
