摘要
褪黑素在生物界分布极为广泛，从低等原核生物到高等脊椎动物，乃至植物体内均发现褪黑素。在漫长的生物进化过程中，它作为一种古老多效性的分子而保留至今。生物界各门类浩繁，形态、功能干差万别，但体内的褪黑素却有相似的作用：（1）传递光暗信号，使生物的各种内源性节律与环境周期保持同步。（2）有效清除生物体内的自由基，使机体免受氧化损伤。（3）褪黑素与钙调蛋白结合，调节细胞骨架的机能状态，以执行特定的功能。褪黑素能使机体与环境保持协调统一，抵御环境不良刺激对机体的影响，保持机体内环境稳定。
Melatonin(MT) is widely distributed over lots of living organisms as different asprokaryotes and vertebrates, even in plants. It is an evolutionary highly conserved molecule existedin body fluid from ancient age to now. In the eaxth, the morpha and function of organisms varyfrom one to another, but the effects of melatonin in all living things are similar: (1) Melatonincan convey light-dark signal and synchronize the internal rhythms to environmental photoperiod.(2) Melatonin is an efficiently free radical scavenger to protect organisms from oxidative damage.(3) By binding to calmodulin melatonin mediate the functional status of cytoskeleton to affect theshape, movement and proliferation of the cell.
出处
《生命科学》
CSCD
2000年第3期130-133,共4页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金
