摘要
目的比较INRatio快速血凝分析仪与标准实验室静脉血测定的国际标准化比值（INR）之间的相关性和一致性，判断INRatio快速血凝分析仪检测INR的临床应用价值。方法选择100例口服华法林患者。同时抽取静脉血及指端末梢血，分别行标准SYSMEXCA-7000全自动凝血仪INR测定及INRatio快速血凝分析仪INR测定。比较两组结果的相关性、一致性。结果当测量INR≤5时，INRatio快速血凝分析仪和SYSMEX CA-7000全自动凝血仪之间显示了良好的相关性（r=0．898，P=0．000）；两种方法总体平均值偏倚差值为0．36，INRatio快速血凝分析仪比SYSMEX CA-7000全自动凝血仪检测值高；通过Bland-Altman分析，两种方法INR平均值在1．60-3．50时，91．2％（62／68）的点在95％的一致性限度内，一致性良好；两种方法INR平均值〉3．50时，仅50．0％（1／2）的点在95％的一致性限度内，一致性差。结论在治疗范围内，INRatio快速血凝分析仪检测的结果表现出与标准实验室结果良好的相关性和一致性，可以应用于临床对口服抗凝药患者INR的检测。
Objective To compare the correlation and agreement of international normalized ratio （INR） measured by INRafio eoagulometer and standard laboratory venous blood measurement in order to judge the clinical application value of measuring INR by INRatio coagulometer. Methods One hundred who received warfarin were chosen randomly. Venous blood and finger capillary blood were taken simultaneously for measurement of INR by laboratory coagulation analyzer SYSMEX CA-7000 and INRatio coaguIometer respectively. The correlation and agreement of INR results tested by the two methods were analyzed. Results When INR ≤5,there was a good correlation between INRatio coagulometer and laboratory coagulation analyzer SYSMEX CA-7000 （r = 0.898, P = 0.000）. The mean bias of the two methods was 0.36 and INR measured by INRatio coagulometer were higher than those tested by laboratory coagulation analyzer SYSMEX CA-7000. By Bland-Ahman,it showed a good agreement for 91.2% （62/68） of the difference INR located 95% the limited of agreement when the mean INR 1.60 - 3.50,and a bad agreement for only 50.0%（1/2） of the difference INR located 95% the limited of agTeement when the mean INR 〉 3.50. Conclusions In the therapeutic range, INR measured by INRatio coagulometer shows a good correlation and agreement with INR measured by the established laboratory method. INRatio coagulometer can be used to monitor INR in the patients received oral anticoagulant therapy.
出处
《中国医师进修杂志》
2012年第24期14-17,共4页
Chinese Journal of Postgraduates of Medicine
关键词
华法林
国际标准化比
血液凝固
Warfarin
International normalized ratio
Blood coagulation
