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罗哌卡因复合吗啡在高龄经尿道前列腺切除术术后患者自控镇痛中的临床研究 被引量:2

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摘要 目的观察罗哌卡因复合吗啡在高龄经尿道前列腺切除术(TURP)术后患者自控镇痛(PCA)中的效果。方法将80例ASA分级Ⅰ-Ⅱ级高龄TURP患者按随机数字表法分为观察组和对照组,每组40例,观察组术毕予硬膜外麻醉管连接PCA泵(美国迈吉电子泵),泵入0.3%罗哌卡因100ml+吗啡10mg,对照组术后主诉明显疼痛时,遵医嘱肌肉注射哌替啶50-100mg,视效果4~6h重复1次,24h内不超过3次。观察、记录患者术后4、8、12、24、48h的视觉模拟评分(VAS),及恶心呕吐和皮肤瘙痒等不良反应,同时比较两组患者的膀胱冲洗时间、肛门排气时间、导尿管拔除时间、住院时间。结果观察组患者术后4、8、12、24、48h的VAS分别为(4.12±0.87)、(4.74±0.95)、(5.03±1.25)、(4.52±0.74)、(4.08±0.71)分,均明显低于对照组的(5.57±1.42)、(5.63±1.54)、(6.28±1.63)、(6.85±0.59)、(7.71±0.50)分,差异有统计学意义(P〈0.05)。观察组肛门排气时间、膀胱冲洗时间、导尿管拔除时间、住院时间分别为(26.7±6.4)h、(4.1±1.4)d、(5.1±2.4)d、(12.2±2.3)d,均明显短于对照组的(29.9±8.2)h、(7.2±1.9)d、(7.6±3.1)d、(15.7±2.7)d,差异有统计学意义(P〈0.05)。两组不良反应比较差异无统计学意义(P〉0.05)。结论应用罗哌卡因复合吗啡在高龄TURP术后行PCA,解除了患者的疼痛,术后不良反应少,同时可缩短膀胱冲洗及导尿管拔除时间,患者可早日下床活动,有利于患者早日康复,值得临床推广应用。
作者 方克
出处 《中国医师进修杂志》 2012年第24期34-35,共2页 Chinese Journal of Postgraduates of Medicine
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