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左旋甲状腺素对老年亚临床甲状腺功能减退患者的疗效 被引量:12

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摘要 目的观察老年亚临床甲状腺功能减退(甲减)伴抗甲状腺过氧化物酶抗体(A-TPO)升高的患者进行甲状腺素补充治疗12个月的疗效。方法共收集84例亚临床甲减伴A-TPO升高患者。所有病例行左旋甲状腺素补充治疗并随访12个月。比较治疗前后中年和老年患者临床症状、甲状腺形态、血脂、体质指数(BMI)及骨代谢的差异。结果补充甲状腺素后,两组患者的甲状腺功能恢复正常。治疗12个月后,甲状腺结节增大20%者,老年组6例,中年组3例,两组差异不大(P>0.05)。通过补充左旋甲状腺素,两组都有部分病人的症状得到缓解。治疗后,两组患者BMI均有所下降,中年组下降更为明显(P<0.05)。两组血脂亦有下降,尤其是总胆固醇(TC)、低密度脂蛋白(LDL)(P均<0.05),且老年组下降更多(P<0.001)。两组治疗前后骨密度(BMD)没有明显差异。结论对亚临床甲减伴A-TPO升高的老年患者进行甲状腺素补充治疗,其疗效至少和中年患者一样有效,未见明显副作用。
作者 杨彬
出处 《中国老年学杂志》 CAS CSCD 北大核心 2012年第17期3687-3689,共3页 Chinese Journal of Gerontology
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参考文献8

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