摘要
目的:检测尿液中视黄醇结合蛋白(Retinol-binding protein,RBP)含量水平,探讨尿液中RBP在高血压、糖尿病早期肾小管损伤中的作用及意义。方法:选取106例糖尿病及高血压病人,分为高血压无肾病组、高血压合并肾病组、糖尿病无肾病组、糖尿病合并肾病组、糖尿病高血压无肾病组和糖尿病高血压合并肾病组等6个组,同时选择55例正常体检病人做对照组。采用OLYMPUS AU2700全自动生化分析仪对各组尿液RBP进行检测,并经统计学分析处理。结果:正常对照组尿液RBP值0.45±0.16;实验组尿液RBP在0.57±0.18～17.22±3.11之间。即高血压和糖尿病病人尿液中的RBP含量均与对照组之间存在显著性差异。结论:尿视黄醇结合蛋白在高血压及糖尿病早期肾小管损伤诊断中具有重要意义,可作为临床诊断高血压及糖尿病早期肾小管损伤的参考指标。
Objective：To determine the content of Urinary Retinol Binding Protein（RBP）in urine and further,and explore the effects and significance of RBP in the diagnosis of early renal tubular injury in patients with hypertention and diabetes.Methods：106 patients with diabetes and hypertention were divided into 6 groups,which were the group of the patients with single hypertention,hypertention complicated with kidney diseases,diabetes without kidney diseases,diabetes complicated with kidney diseases,diabetes complicated with hypertension and the patients complicated with diabetes,hypertention and kidney diseases.Meanwhile,55 healthy patients were setted as normal control group.OLYMPUS AU2700 fully automatic biochemistry analyzer was used to assay RBP in each group.Results：The RBP Value was 0.45±0.16 in normal group,the RBP value were between 0.57±0.18 and 17.22±3.11 in experience group.which implies the RBP in the hypertention patients complicated with diabetes is significantly different from group.Conclusions：Assay of RBP is important to make a diagnosis of early renal tubular injury in patients with hypertention and diabetes,which can be termed as a reference index in diagnosing early renal tubular injury in patients with hypertention and diabetes.
出处
《内蒙古医学院学报》
2012年第3期221-224,共4页
Acta Academiae Medicinae Neimongol
关键词
尿视黄醇结合蛋白
高血压
糖尿病
早期肾小管损伤
urinary retinol binding protein （RBP）
hypertention
diabetes
early renal tubular injury
