摘要
目的:通过对420例肿瘤患者甘露聚糖肽注射液皮试方法及结果的研究,以确定安全可靠的皮试液浓度,从而指导临床正确、科学的使用甘露聚糖肽。方法:予甘露聚糖肽注射液(多抗)以生理盐水稀释至100倍配制成皮试液,吸取皮试液0.1ml进行皮内注射。皮试期间注意观察病人有无药物过敏等不良反应发生,皮试阴性患者予甘露聚糖肽注射液10mg加入0.9%氯化钠注射液250ml缓慢静脉滴注,40滴/min。观察滴注期间和滴注后24小时患者一般情况、有无过敏、出现不良反应的时间和异常症状。结果:420例患者阳性3例(0.71%),可疑阳性2例(0.48%),阴性415例(98.81%);皮试阴性者输注过程中无一例发生速发型变态反应,8例患者发生轻微不良反应,经吸氧、止吐等处理措施后,症状消失。结论:甘露聚糖肽输注前进行皮试可减少过敏反应的发生;将甘露聚糖肽注射液(多抗)稀释100倍进行皮试,安全可靠,为较佳的甘露聚糖肽皮试液。鉴于不同生产厂家生产工艺不同,相应的皮试研究结论可能存在一些差别。
Objective：To investigate the characteristics of 420 cases cancer patients skin allergy test and results induced by mannan glycopeptides injection,in order to determine the safe and reliable skin test concentration and to use mannatide correctly and scientificly.Methods：After mannan glycopeptides injection were diluted to 100 times as skin test liquid with normal saline,absorbed 0.1ml skin test liquid to inject inside skin.During observation patient＇s skin test,paid attention to whether drug allergy and adverse reaction occuring;those who skin test negatie patients were arranged 10mg mannan glycopeptides injection joinning into 0.9% sodium chloride liquid 250ml,and slow intravenous drip,infusion rate 40/min,and observated whether with allergies,harmful response time and abnormal symptoms during infusion solution and within 24 hours after the general situation.Results： skin allergy test positive 3 cases（0.71%）,suspicious positive 2 cases（0.48%）,negative 415 cases（98.81%）;None of the 415 cases those skin test negative occurred Immediate allergic reaction in the process of infusion,8 casesoccurs minor adverse reactions,after oxygen,antiemetics,and other measures,the symptoms disappeared Conclusion：Adverse reactions will reduce if mannan glycopeptides injection skin test was carry out before the infusion.As skin test,mannan glycopeptides injection diluted to 100 times was safe,reliable which can maximumscreen allergic patients.In view of the different manufacturers of different production processes,the corresponding skin test methods are different.
出处
《中国医药导刊》
2012年第8期1386-1387,共2页
Chinese Journal of Medicinal Guide
关键词
甘露聚糖肽
皮试
不良反应
Mannan glycopeptides
Skin allergy test
Adverse drug reaction
