摘要
目的观察术中泵注右美托咪定(Dex)联合氟比洛芬酯对全麻下行甲状腺手术患者术后镇痛的影响。方法择期行甲状腺手术患者63例,ASAⅠ或Ⅱ级,随机均分为三组。D1组和D2组于麻醉诱导前静脉泵注Dex0.6μg/kg(泵注时间为10min),D2组术中以0.4μg·kg-1·h-1持续泵注;C组以同样的方式泵注等量生理盐水。三组均于麻醉诱导后手术开始前静脉给予氟比洛芬酯1.0mg/kg。记录患者术后疼痛VAS评分、舒适评分(BCS评分),并记录术后首次给予氟比洛芬酯的时间及术后不良反应。结果术后定向力恢复后10min～2h,D1、D2组VAS评分明显低于C组,且D2组明显低于D1组(P<0.05);术后4h,D2组VAS评分明显低于C组(P<0.05)。定向力恢复后10min～4h,D1、D2组BCS评分明显高于C组,且定向力恢复后10min～2hD2组明显高于D1组(P<0.05)。术后首次给予氟比洛芬酯时间,D1、D2组均明显晚于C组,且D2组明显晚于D1组(P<0.05)。结论持续泵注右美托咪定联合氟比洛芬酯用于全麻下甲状腺手术患者的术后镇痛效果满意,优于单独应用氟比洛芬酯。
Objective To investigate the postoperative analgesic effect of dexmedetomidine combined with flurbiprofen axetil in patients undergoing thyroidectomy under general anesthesia. Methods Sixty-three patients, ASA Ⅰ or Ⅱ , scheduled for thyroidectomy surgery under general anesthesia were randomly divided into 3 groups （n = 21 ） .. dex-single group （group D1 ）, dexcontinuous group （group D2 ） and control group （group C）. Dexmedetomidine 0.6 mg/kg was intravenously infused over 10 min before induction of anesthesia in groups D1 and D2. Then dexmedetomidine was intravenously infused at a rate of 0.4 mg. kg ^-1 h ^-1 during the operation in group D2 and the same volume of normal saline was infused in group D,. Normal saline was infused at the same volume before and during the operation in group C. All groups received flurbiprofen axetil 1.0 mg/kg intravenously before surgery. The postoperative surgical pain was assessed by Visual Analogue Scale （VAS） and Bruggmann Comfort Scale （BCS） at 10 min, 30 min, 1 h, 2 h, 4 h and 24 h after the orientation recovery. The time of postoperative first application of flurbiprofen axetil was recorded. Results VAS was lower at 10 rain-2 h after the orientation recovery in group D1 and group D2 than in group C, and was lower at 10 min-2 h in group De than in group D1 （P〈0.05）. BCS was higher at 10 min4 h in group D1 and group D2 than in group C, and was higher at 10 min-2 h in group D2 ,than in group D1 （P〈0.05）. The time of first application of flurbiprofen axetil was later in group D1 and group D2 than in group C （P〈0.05）, Conclusion Dexmedtomidine combined with comfortable postoperative analgesia than thyroidectomy under general anesthesia. and was later in group D2 than in group D1 （P〈0.05）. flurbiprofen axetil can provides more satisfactory and flurbiprofen axetil alone for patients undergoing
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2012年第8期736-738,共3页
Journal of Clinical Anesthesiology
关键词
右美托咪定
甲状腺手术
氟比洛芬酯
术后镇痛
Dexmedetomidine
Thyroidectomy
Flurbiprofen axetil
Postoperative analgesia
