摘要
目的探讨急性ST段抬高心肌梗死(STEMI)患者术前强化阿托伐他汀治疗的中期临床疗效。方法对拟行急诊PCI治疗的102例STEMI患者随机分为A组32例,B组32例,C组38例。观察术后90 min内ST段回落、术后24、72 h高敏C反应蛋白(hs-CRP)、术后肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)峰值及术后6个月主要不良心血管事件。结果 3组患者入院和术后24 h hs-CRP比较,差异无统计学意义(P>0.05)。与A组比较,B组、C组术后72 h hs CRP明显升高(P<0.05)。术前3组CK与CK-MB比较,差异无统计学意义(P>0.05)。与A纽比较,B组、C组术后CK、CK-MB明显升高,ST段回落均值及发生率明显降低(P<0.05)。A组、B组、C组术后6个月主要心血管不良事件发生率分别为9.4%、9.4%和10.5%,差异无统计学意义(P>0.05)。结论急诊PCI术前强化阿托伐他汀治疗可抑制STEMI患者炎性反应,减轻心肌梗死范围。
Objective To observe the intermediate clinical outcome in patients with STEMI who re- ceived intensive atorvastatin treatment before emergency PCI. Methods STEMI patients under- going emergency PCI were randomly divided into group A（n=32）, group B（n= 32）and group C （n：38）. Patients in group A received 80 mg atorvastatin daily before PCI followed by 40 mg ator- vastatin daily for 1 month and a maintenance dose of 20 mg atorvastati daily thereafter. Patients in group 13 were given 40 mg atorvastatin daily for 1 month after PCI and a maintenance dose of 20 mg atorvastatin daily thereafter. Patients in group C administered 20 mg atorvastatin daily after PCI. STR were evaluated at 90 min after PCI,hs-CRP were assayed 24 h and 72 h after PCI. Peak CK and CK-MB levels were measured and MACE were recorded 6 months after PCI. Results No significant difference was found in hs-CRP level among the 3 groups at admission and 24 h after PCI（P〉0.05）. The hs-CRP level was significantly higher in groups B and C than in group A at 72 h after PCI（P〈0.05）while no significant difference was observed in hs-CRP level between groups B and C. No significant difference was found in CK and CK-MB level among the 3 groups before PCI. The peak CK and CK-MB levels were significantly higher while the average value and incidence of STR were significantly lower in groups B and C than in group A（P〈0.05）. The inci- dence of MACE was 9.4% ,9.40/60 and 10.5% respectively in 3 groups（P〉0.05）. Conclusion In- tensive atorvastatin treatment of STEMI patients before emergency PCI can inhibit inflammatory reactions and alleviate myocardial infarction.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2012年第9期903-906,共4页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
