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血清TNF-α、t-PSA、f-PSA联合检测在前列腺癌鉴别诊断中的意义 被引量:1

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摘要 目的探讨血清TNF-α和总前列腺特异性抗原(t-PSA)及游离PSA(f-PSA)联合检测在前列腺癌鉴别诊断中的意义。方法采用ELISA法检测56例前列腺癌(PCA)患者(PCA组)、50例前列腺增生(BPH)患者(BPH组)及35例男性健康体检者(对照组)的血清TNF-α、f-PSA、t-PSA,计算f/tPSA。结果与对照组比较,PCA组患者血清t-PSA、f-PSA、TNF-α水平明显增高(P均<0.05),f/tPSA明显减小(P<0.05);与BPH组比较,PCA组血清TNF-α水平明显增高(P<0.05),f/tPSA明显减少(P<0.05);与对照组相比较,BPH患者血清t-PSA、f-PSA水平显著增高(P均<0.05)。血清TNF-α水平随PCA肿瘤分化程度降低逐渐增加(P均<0.05)。结论联合检测血清t-PSA、f-PSA、TNF-α有助于PCA的鉴别诊断,对PCA的病情评估有一定意义。
出处 《山东医药》 CAS 2012年第30期80-81,共2页 Shandong Medical Journal
基金 湖南省衡阳市2011年科学技术发展计划项目(2011KJ49)
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