摘要
目的探讨"治未病"理论指导下,中药干预对内镜下摘除腺瘤性大肠息肉患者的影响。方法选择符合标准的腺瘤性大肠息肉患者140例,根据辨证分型将患者分为脾虚湿瘀组(A组)、湿热瘀阻组(B组)和气滞血瘀组(C组),每组再根据服不服用中药分为两个亚组:中药治疗组(A1组)和非中药治疗组(A0组)、中药治疗组(B1组)和非中药治疗组(B0组)、中药治疗组(C1组)和非中药治疗组(C0组),治疗周期为6个月,1年后复查肠镜。结果 A1组患者经治疗后症状明显改善,治疗前总平均症状积分为(3.00±0.96)分,治疗后为(0.87±0.62)分,差异有统计学意义(t=13.07,P<0.05)。Spearman相关分析显示,腺瘤性大肠息肉个数与复发率呈正相关(r=0.191,P<0.05)。6个亚组复发率由低到高的顺序为:C1(9.1%)<A1(12.5%)<B1(18.2%)<A0(30.6%)<B0(60.9%)<C0(87.5%),以脾虚湿瘀证患者复发率最低,气滞血瘀证患者复发率最高;各中药治疗亚组复发率均低于其相对的非中药治疗亚组,差异均有统计学意义(χ2A1:A0=3.72,χ2B1:B0=8.54,χ2C1:C0=11.68,P<0.05)。本组140例患者中有1例患者发生癌变,经中药治疗后管状腺瘤、绒毛状腺瘤及混合型腺瘤患者例数均减少。结论在"治未病"理论指导下,中药干预能有效改善腺瘤性大肠息肉患者临床症状,有效降低内镜下摘除腺瘤性大肠息肉患者的复发率。
Objective To explore the effects of TCM intervention on patients with adenomatous colonic polyps（ACP） under the guide of ＂preventive treatment of diseases ＂.Methods One hundred and forty ACP patients were divided,according to syndrome differentiation,into groups A（spleen wet stasis group）,B（dampness and hotness obstruction group）,C（Qi depression to blood stasis）.Group A were subdivided into groups A1（TCM group） and A0（non-TCM）,group B into B1（TCM group） and B0（non-TCM）,group C into C1（TCM group） and C0（non-TCM）.The treatment lasted 6 months.Colonoscopy review performed after one year.Results Symptoms improved in TCM groups,the total average symptom score was（3.00±0.96） before treatment and（0.87±0.62） after,the difference was significant（t=13.07,P0.05）.Spearman correction analysis showed that number of ACP was positively correlated with relapse rate（r=0.191,P0.05）.Relapse rates of 6 subgroups were,from low to high,C1（9.1%）A1（12.5%）B1（18.2%）A0（30.6%）B0（60.9%）C0（87.5%）,lowest in group A,highest in group C.The relapse rates lower in subgroups TCM than subgroups non-TCM,the difference was significant（χ2A1：A0=3.72,χ2B1：B0=8.54,χ2C1：C0=11.68,P0.05）.Conclusion Under the guide of theory ＂preventive treatment of diseases ＂,TCM intervention can improve effectively clinical symptoms of ACP patients,reduce the relapse rate after endoscopic removal.
出处
《中国全科医学》
CAS
CSCD
北大核心
2012年第23期2718-2720,共3页
Chinese General Practice
基金
广东省科技计划项目(2011B0613000078)
关键词
肠息肉
腺瘤性息肉
复发
中草药
Intestinal polyps
Adenomatous polyps
Recurrence
Drugs, chinese herbal
