客观评价脓毒症生物标志物的临床意义被引量：37

导出

摘要脓毒症（sepsis）及其诱发的多器官功能障碍综合征（MODs）仍然是目前重症监护病房（ICU）的主要死因，且其发生率呈上升趋势。由于临床上仍缺乏早期敏感性诊断手段，目前病死率依然很高。随着分子生物学和现代生物技术的不断发展，人们发现多种生物标志物（biomarker）在脓毒症的早期诊断、病情及预后判断、疗效评估中发挥重要作用。因此，深入了解脓毒症病理生理机制中不同生物标志物的意义及价值，对于脓毒症及其并发症的早期识别及干预，降低患者的病死率及提高生活质量具有积极意义。

作者姚咏明栾樱译

机构地区解放军总医院第一附属医院全军烧伤研究所

出处《中国危重病急救医学》 CAS CSCD 北大核心 2012年第9期517-519,共3页 Chinese Critical Care Medicine

基金国家自然科学基金（81130035,30971192,81071545）国家重点基础研究发展计划项目（2012CB518102,2005CB522602）

关键词生物标志物临床意义脓毒症多器官功能障碍综合征重症监护病房现代生物技术病理生理机制早期诊断

分类号 R459.7 [医药卫生—急诊医学]

引文网络
相关文献

参考文献20

1Zeitoun AA, Gad SS, Attia FM, et al. Evaluation of neutrophilic CD64, interleukin 10 and proealeitonin as diagnostic markers of early- and late-onset neonatal sepsis. Scand J Infect Dis, 2010,42 : 299-305.
2Lannerg~d A,Larsson A,Friman G,et al. Human serum amyloid A (SAA) and high sensitive C-reactive protein (hsCRP) in preterm newborn infants with nosocomial infections. Acta Paediatr, 2008,97 : 1061-1065.
3Becker KL, Snider R, Nylen ES. Procalcitonin assay in systemic inflammation,infection, and sepsis:clinical utility and limitations. Crit Care Med, 2008,36:941-952.
4Nakamura A, Wada H, Ikejiri M, et at. Efficacy of procalcitonin in the early diagnosis of bacterial infections in a critical care unit. Shock, 2009,31 : 586-591.
5Martini A, Gottin L, Menestrina N, et al. Procalcitonin levels in surgical patients at risk of candidemia. J Infect, 2010,60 : 425-430.
6Tang BM, Eslick GD, Craig JC,et al. Accuracy of procalcitonin for sepsis diagnosis in critically ill patients:systematic review and meta-analysis. Lancet Infect Dis, 2007,7 : 210-217.
7Bouchon A,Facchetti F,Weigand MA,et al. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature,2001,410: 1103-1107.
8Gibot S, Kolopp-Sarda MN, Bene MC, et al. Plasma level of a triggering receptor expressed on myeloid cells-1 : its diagnostic accuracy in patients with suspected sepsis. Ann Intern Med, 2004, 141 : 9 - 15.
9Hunt PJ, Espiner EA, Nicholls MG, et al. Differing biological effects of equimolar atrial and brain natriuretic peptide infusions in normal man. J Clin Endocrinol Metab, 1996,81 : 3871-3876.
10Rudiger A, Gasser S, Fischler M, et al. Comparable increase of B-type natriuretic peptide and amino-terminal pro-B-type natriuretic peptide levels in patients with severe sepsis, septic shock, and acute heart failure. Crit Care Med, 2006,34:2140-2144.