摘要
目的总结海南省2010-2011年先天性甲状腺功能减低症(Congenital hypothyroidism,CH)的筛查情况及治疗情况。方法采集出生72h新生儿158524例的足跟血滴于,滤纸上,采用时间分辨荧光免疫测试法测定促甲状腺素(TSH),召回阳性者进一步测定静脉血甲状腺功能,明确诊断。确诊者立即开始给予左旋甲状腺素片替代治疗,定期检测甲状腺功能,并进行生长发育评估及智力测试,以评估疗效。结果初筛阳性患儿1507例,确诊先天性甲状腺功能减低症50例,两年来发病率为1/3170。其中43例坚持治疗随访中,目前监测甲状腺功能正常,体格生长发育及智力测试均与正常同年龄小儿相当。结论新生儿筛查可使先天性甲状腺减低症患儿尽早得到有效治疗,改善预后。因此应加大新生儿CH筛查及治疗重要性的宣传力度,进一步提高CH患儿的治疗率及健康水平。
Objective To summarize the screening results of neonates with congenital hypothyroidism （CH） in Hainan province from Jan. 2010 to Dec. 2011, and to analyze the clinical efficacy of the treatment. Methods The screening procedure was based on the determination of thyroid stimulating hormone （TSH） in dried blood spots ob- tained by heel puncture 72 hours after birth. Neonates with CH were treated with levothyroxine （L-T4）. The thyroid function, condition of growth and intelligence status were investigated to evaluate the efficacy of therapy during the follow-up.＇Results A total of 158 524 neonates were screened, of which 1 570 positive cases were called back for di- agnosis test and fifty cases of CH were confirmed with an average incidence rate of 1/3 170. During the follow-up, the thyroid function, growing development and intelligence of the forty-three patients who insisted on treatment had gone back to normal. Conclusion Neonates with CH confirmed by neonatal screening have chance of receiving early treat- ment and achieving satisfactory prognosis. Therefore, neonates screening and follow-up study are worthy to be im- proved and popularized.
出处
《海南医学》
CAS
2012年第17期94-96,共3页
Hainan Medical Journal
