摘要
目的观察盐酸司维拉姆(Renagel)在维持性血液透析(MHD)患者应用骨化三醇冲击治疗继发性甲状旁腺功能亢进时对高磷血症的影响。方法将18例血清全段状旁腺激素(iPTH)33～55pmol/L的MHD患者给予口服Renagel 800mg,3次/d,并予骨化三醇1.0μg,2次/周冲击治疗;对照组16例予碳酸钙D 900mg/d联合骨化三醇冲击治疗。监测两组患者血钙、血磷及iPTH。结果Renagel组2个月后血磷及iPTH较治疗前明显下降,血磷较对照组有明显下降,差异有统计学意义(P<0.05)。结论司维拉姆能有效改善MHD患者应用骨化三醇冲击治疗继发性甲状旁腺功能亢进时的高磷血症。
Objective To investigate the effect ofsevelamer hydrochloride （renagel） on hyperphosphatemia in maintenance hemodialysis （MHD） patients with secondary hyperparathyroidism （SHPT） treated by calcitriol pulse theraphy. Methods Thirty-four MHD patients, with intact parathormone （iPTH） levels of 33-55 pmol/L, were treat- ed with calcitriol （1.0 pg, biw） pulse therapy. Eighteen of the patients （the study group） were treated with oral renagel （800 rag/d, tid）, and 16 of the patients （the control group） were treated with calcium carbonate 900 mg/d. Serum phos- phate, calcium and iPTH were examined within 2 months of therapy.
出处
《海南医学》
CAS
2012年第18期37-38,共2页
Hainan Medical Journal
