期刊文献+

P-选择素联合高敏C-反应蛋白对冠脉支架内再狭窄的预测价值 被引量:1

Prediction of in stent restenosis by P-Selectin and Hs-CRP in patients with coronary artery disease
下载PDF
导出
摘要 目的通过血管内超声(IVUS)评估冠状动脉支架内再狭窄(ISR),随访并观察冠脉介入术(PCI)后ISR组与非ISR组患者炎症因子的水平,探讨P-选择素(P-Selectin)联合高敏C-反应蛋白(Hs-CRP)预测ISR的可行性。方法对133例经皮冠脉介入术后患者进行冠脉造影及IVUS检查随访,造影证实ISR组17例,共22个病变;非ISR组103例,共138个病变;测量并比较两组外弹力膜横截面面积(EEM)、斑块面积、最小管腔面积(MLA)及内膜增生面积;术前及随访时均检测血清P-Selectin、Hs-CRP水平。结果与非ISR组比较,ISR组有更大的斑块面积、内膜增生面积及更少的最小管腔面积。其中斑块面积、内膜面积、最小管腔面积比较,差异具有统计学意义(P>0.05);外弹力膜横截面积比较差异无统计学意义(P>0.05)。非ISR组经皮冠脉介入术前后P-Selectin、Hs-CRP水平比较,差异无统计学意义(P>0.05),ISR组术后P-Selectin、Hs-CRP较术前明显升高,差异有统计学意义(P<0.05)。结论经皮冠脉介入术后支架内再狭窄患者P-Selectin、Hs-CRP水平较术前升高,监测Hs-CRP及P-选择素水平对PCI术后ISR有一定的预测作用。 Objective To learn the relationship between concentration of P-Selectin, Hs-CRP and instent restenosis(ISR) after percutaneous coronary intervention(PCI). Methods A total of 133 patients with coronary artery disease were followed up and divided to 2 group according the coronary angiography results. The instent restenosis group included 17 patients with 22 lesions while non in-stent restenosis (non ISR) group included 103 patients with 138 lesions. All of them were performed intravascular ultrasound(lVUS) and the extra-elastic membrance cross-sectional area(EEM CSA), plaque area, minimal lumen area(MLA), and intima proliferation area were recorded Besides, P-Selectin and Hs-CRP in all patients were detected. Results The plaque area and intima proliferation area were larger in ISR group compared with that in non-ISR group(P 〈 0.05), while MLA were smaller. (P 〈 0.05), EEM CSA were not statistically different between two groups. In ISR group, the concentration of P-Selectin and Hs-CRP were significantly elevated after PCI(P 〈 0.05 vs. pre-PCI), whereas there was no significant difference in non ISR group. Conclusion P-Selectin, Hs-CRP were increased post-PCI in ISR patients. Monitoring changes of P-Selectin and Hs-CRP may be beneficial for prediction of ISR post-PCI.
出处 《中国医药科学》 2012年第17期22-23,73,共3页 China Medicine And Pharmacy
基金 广东省东莞市科技计划医疗卫生类科研项目(20091051500109)
关键词 血管内超声 冠状动脉造影术 再狭窄 P-选择素 高敏C反应蛋白 Intravascular uhrasound Coronary angiography Instent restenosis P-Selectin High-sensitive C-reactive protein
  • 相关文献

参考文献9

  • 1Sprague EA.In vivo cardiovascular assays for drug discovery: evolution of the drug-eluting stent[J].Curr Opin Investig Drugs, 2007,8 ( 3 ) : 219-225.
  • 2Philippe F, Dibie A, Larrazet F, et al.Drug eluting stents: finm evidence based medicineto clinical pmetiee[J].Ann Cawliol Angeiol (Paris), 2005,54 ( 4 ) : 201-211.
  • 3Curt'ado E, Novo S.Role of inflammation and infection.in vascular disease[J]. Acta Chir Belg,2005,5 ( 6 ) : 567-579.
  • 4Suzuki Y, Lyons JK, Yeung AC, et al.The porcine restenosis model using thermal balloon injury:comparison with the model by coronary stenting[J]. J Invasive Cardiol, 2008,20 ( 3 ) : 142-146.
  • 5Kubica J, Koinski M, Krzewina-Kowalska A, et al.Combined periprocedural evaluation of CRP and TNF-alpha enhances the prediction of clinical restenosis and major adverse cardiac events in patients undergoing perentaneons coronary interventions[J].Inl JMol Med, 2005,16 ( 1 ) : 173-180.
  • 6Bhatt DL.Anti-inflammatory agents and antioxidants as a possible"lhird great wave"in cardiovascular secondary prevenlion [J].Am J Cardiol, 2008,22,101 ( 10A ): 4D-13D.
  • 7Dibra A, Mehilli J, Braun S, et al.lnflammalnry response afler intervention assessed hy serial C-reactive proleinments correlates with restenesis in patients treated with ctbronary stenting[J ].Am Heart J, 2005,150 ( 2 ): 344-350.
  • 8Wang K, Zhou X, Zholl Z, el al.Platelet, not endothelial, P-selectin is required for neointimal formation after vascular injury[J].Arterioscler Thromb Vase Biol, 2005,25 ( 8 ): 1584-1589.
  • 9Tanguay JF, Geoffroy P, Sirois MG, et al.Prevention of in-stent restenosis via reduction of thrombo-inflammatory reactions with recombinant P-selectin glycoprotein ligand- 1 [J].Thromb Haemost.2004,91 ( 6 ) : 1186-1193.

同被引文献11

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部