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Emerging approaches to probing ion channel structure and function 被引量:1

Emerging approaches to probing ion channel structure and function
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摘要 Ion channels,as membrane proteins,are the sensors of the cell.They act as the first line of communication with the world beyond the plasma membrane and transduce changes in the external and internal environments into unique electrical signals to shape the responses of excitable cells.Because of their importance in cellular communication,ion channels have been intensively studied at the structural and functional levels.Here,we summarize the diverse approaches,including molecular and cellular,chemical,optical,biophysical,and computational,used to probe the structural and functional rearrangements that occur during channel activation(or sensitization),inactivation(or desensitization),and various forms of modulation.The emerging insights into the structure and function of ion channels by multidisciplinary approaches allow the development of new pharmacotherapies as well as new tools useful in controlling cellular activity. Ion channels,as membrane proteins,are the sensors of the cell.They act as the first line of communication with the world beyond the plasma membrane and transduce changes in the external and internal environments into unique electrical signals to shape the responses of excitable cells.Because of their importance in cellular communication,ion channels have been intensively studied at the structural and functional levels.Here,we summarize the diverse approaches,including molecular and cellular,chemical,optical,biophysical,and computational,used to probe the structural and functional rearrangements that occur during channel activation(or sensitization),inactivation(or desensitization),and various forms of modulation.The emerging insights into the structure and function of ion channels by multidisciplinary approaches allow the development of new pharmacotherapies as well as new tools useful in controlling cellular activity.
机构地区 Neuroscience Division
出处 《Neuroscience Bulletin》 SCIE CAS CSCD 2012年第4期351-374,共24页 神经科学通报(英文版)
基金 supported by grants from the National Natural Science Foundation of China(91132303,30830035) the National Basic Research Development Program of China (2011CBA00408) the China Postdoctoral Science Foundation(2012M511105)
关键词 ion channel structure and function MUTAGENESIS covalent modification voltage-clamp fluorometry computational chemistry ion channel structure and function mutagenesis covalent modification voltage-clamp fluorometry computational chemistry
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