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肺巨噬细胞凋亡路径与急性肺损伤关系研究进展 被引量:4

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摘要 急性肺损伤(acute lung injury,ALI)是各种直接和间接致伤因素导致的肺泡上皮细胞及毛细血管内皮细胞损伤,可造成弥漫性肺间质及肺泡水肿,导致急性低氧性呼吸功能不全。近年的资料表明,肺巨噬细胞(alveolar macrophages,AM)的凋亡延迟在ALI中起到举足轻重的作用。研究AM凋亡调控的机制,可进一步掌握炎症反应的发生发展过程,为防治ALI提供新的靶点。
出处 《社区医学杂志》 2012年第18期51-54,共4页 Journal Of Community Medicine
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  • 1Takemura Y, Iwasaki Y, Nagata K, et al. Influence of depletion of alveolar macrophages on apoptosisi in Candida - induced acute lung injury [J]. Exp Lung Res,2005,31 (3) :307 -321.
  • 2黄希,邓立普.急性肺损伤中信号通路及相关受体研究进展[J].医学综述,2010,16(20):3054-3057. 被引量:9
  • 3Haychaudhuri B,Fisher CJ,Farver CF,et al. Interleukin 10 (IL -10) mediated inhibition of inflammatory cytokine production by human alveolar macrophages [ J. Cytokine, 2000, 12 ( 9 ) : 1348 -1355.
  • 4黎庶,汪正清.LPS诱导巨噬细胞凋亡的研究[J].中华微生物学和免疫学杂志,2003,23(7):540-543. 被引量:10
  • 5Suda K ,Takeuchi H ,Hagiwara T,et al. Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis [ J]. Shock,2010,33(5) :526 -531.
  • 6Aikawa N , Ishizaka A,Hirasawa H , et al. Reevaluation of the efficacy and safety of the neutrophil elastase inhibitor, Sivelestat, for the treatment of acute lung injuiy associated with systemic inflammatory response syndrome : a phase IV study[ J]. Pulm Pharmacol T-her ,2011 ,24(5):549-554.
  • 7Morimoto K,Nishimura K,Miyasaka S , et al. The effect of sivelestat sodium hydrate on severe respiratory failure after thoracic aortic surgery with deep hypothermia[ J]. Ann Thorac Cardiovasc Surg, 2011,17(4):369-375.
  • 8Thorbum A, Behbakht K, Ford H. TRAIL receptor - targeted therapeutics :resistance mechanisms and strategies to avoid them [ J]. Drug Resist Updat,2008,11 (1/2) :17 - 24.
  • 9Pinkoski MJ, Brunner T, Green DR, et al. Fas and Fas ligand in gut and Live[ J]. Am J Phisiol Gastrointest Liver Physiol, 2000,278 :354 -366.
  • 10M llauer L, gruber P, Sebinger D, et al. Mutations in apoptosis genes. a pathogenetic factor for human disease [ J]. Mutat Res, 2001,488:211 -231.

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