摘要
目的探讨男性不育症与异常染色体核型的关系。方法采用常规G显带方法对1124例不育男性患者行细胞遗传学检查。结果检出异常核型121例,异常检出率10.77%。其中Klinefelter's syndrome 49例,占异常核型40.5%;Y染色体形态异常35例,占异常核型28.9%;染色体多态性变化14例,占异常核型11.6%;染色体臂间或臂内倒位携带者2例,占异常核型1.7%;平衡易位携带者17例,占异常核型14.0%;染色体嵌合体4例,占异常核型3.3%。结论染色体核型异常是男性不育症的主要原因之一,对男性不育症患者进行细胞遗传学分析,可为临床诊断和治疗提供科学依据。
Objective：To study the relationship between male infertility and abnormal chromosome karyotypes.Methods： Giemsa banding chromosome analysis was done in 1124 cases of male infertility for routine cytogenetic analysis.Results：There were 121 cases of abnormal karyotypes which is 10.77% in all examiners.They included 49 cases of Klinefelter′s syndrome which was 40.5% in all abnormal karyotypes;There were 35 cases of Y chromosome abnormal morphology which were 28.9% in chromosome abnormalities;They included 14 cases of chromosome polymorphism changes which were 11.6% in all abnormal karyotypes.There were 2 cases with chromosome inversion which were 1.7% in all abnormal karyotypes;17 cases with balanced translocation were checked out,which were 14.0% in chromosome abnormalities;There were 4 cases of chromosome chimeare which were 3.3% in all abnormal karyotypes.Conclusion： The abnormality of chromosome karyotype should be one of the basic reasons of male infertility.Cytogenetics analysis to male infertility can provide aids on the diagnosis and treatment of infertility couples.
出处
《中国优生与遗传杂志》
2012年第9期39-41,F0002,共4页
Chinese Journal of Birth Health & Heredity
关键词
男性不育
异常核型
细胞遗传学分析
Male infertility
Abnormal karyotype
Cytogenetics analysis
