摘要
目的:研究重楼克感滴丸对流感病毒FM1感染小鼠的保护作用及作用机制。方法:将小鼠分为空白对照组、模型组、利巴韦林组及重楼克感滴丸大、中、小剂量组,观察小鼠行为状态、死亡率、肺指数及肺指数抑制百分率。结果:重楼克感滴丸各剂量组有明显改善流感病毒FM1感染小鼠行为状态的作用;重楼克感滴丸中、小剂量组与模型组比较,死亡率显著降低(P<0.01);重楼克感滴丸大、中、小剂量组均能显著降低流感病毒FM1感染小鼠模型的肺指数(P<0.01)。结论:重楼克感滴丸中、小剂量组对流感病毒FM1感染小鼠具有明显保护作用,其作用机制与重楼克感滴丸能显著抑制病毒在体内的增殖、减轻肺部炎性病变有关。
Objective： To research the protective effect of Chonglou Kegandiwan on the mice infected with influenza virus FM1 and the effecting mechanism. Methods： The experimental mice were divided into control group, model group, ribavirin group, Chonglou Kegandiwan high, middle, low dose group, and then observed the experimental rats＇ behavior, mortality, lung index and the percentage of lung index inhibition separately. Results： Each Chonglou Kegandiwan dose group could improve the behavior of the mice infected with influenza virus FMI distinctly. Compared with the model group, the mortality of Chonglou Kegandiwan middle and low dose group decreased significantly. It indicated that Chonglou Kegandiwan have a protective effect on the mice infected with influenza virus FM1. Each Chonglou Kegandiwan dose group could reduce the lung index of the mice infected with influenza virus FMI remarkably, which illustrated that Chonglou Kegandiwan could markedly restrain the proliferation of the influenza virus FM1 in the body of the mice, and relieve the inflammatory lesion in the lung of the mice. Conclusions： The Chonglou Kegandiwan middle and low dose group have a evident protective effect on the mice infected with influenza virus FM1, and the effecting mechanism probably be involved that Chonglou Kegandiwan can markedly restrain the proliferation of the influenza virus FM1 in the body and relieve the inflammatorylesion in the lung.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2012年第9期2451-2453,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
重大新药创制科技重大专项(No.2009ZX09102-142)~~
