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添加抗抑郁药物治疗功能性消化不良的疗效观察 被引量:3

The Efficacy Observation of Antidepressant Therapy in Functional Dyspepsia
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摘要 目的:探讨抗抑郁药物联合质子泵抑制剂(PPI)和胃肠动力药治疗功能消化不良(functional dyspepsia,FD)的临床疗效。方法:选择2010年6月-2011年4月功能性消化不良患者152例,随机分为治疗组和对照组。治疗组在口服奥美拉唑20mg,1次/d,莫沙必利片5mg,3次/d的基础上添加三环抗抑郁药多虑平25mg,每晚睡前1次;对照组仅给予奥美拉唑胶囊20mg,1次/d,莫沙必利片5mg,3次/d,治疗4周。结果:治疗组显效率为69.6%,总有效率为89.9%;对照组显效率为27.4%,总有效率为65.8%,两组间比较有显著性差异(P<0.01)。结论:功能性消化不良与精神心理因素有关,添加小剂量多虑平、质子泵抑制剂及胃肠动力药联合治疗FD可显著提高临床疗效,无明显副反应。 Objective:To explore the clinical effect of antidepressant drugs combined with proton pump inhibitors and gastrointestinal motility drugs in the treatment of functional dyspepsia. Methods: 152 patients with functional dyspepsia were selected and randomly divided into treatment group and control group. The patients in treatment group were trea- ted with 20mg omeprazole and 5rag mosapride citrate tables three times plus 25mg doxepin before sleep everyday; while the patients in control group were treated with 20rag omeprazole capsule and 5rag mosapride citrate tables three times everyday only for 4 weeks. Results: The obvious effective rate of treatment group was 69. 6%, the total effective rate was 89. 9~;the obvious effective rate of control group was 27.4~, the total effective rate was 65. 8~, there was very significant difference between two groups (P〈0. 01). Conclusion:FD correlates with psychic factors, and antidepressant therapy in functional dyspepsia may significantly improve the clinical effect.
出处 《医学理论与实践》 2012年第18期2205-2206,2214,共3页 The Journal of Medical Theory and Practice
关键词 功能性消化不良 精神心理因素 抗抑郁治疗 多虑平 Functional dyspepsia, Psychic factors, Antidepressant therapy, Doxepine
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