摘要
目的 探讨老年人脑梗塞脑脊液 (CSF)及血清中肿瘤坏死因子 (TNF)的变化及其与年龄的关系。 方法 用ELISA(双抗体夹心 )方法对 45例老年脑梗塞患者CSF及血清TNF α进行检测 ,并与 31例中青年脑梗塞和 30例健康人进行比较。 结果 老年组CSF中TNF α含量明显高于对照组 (P <0 0 1)及中青年组 (P <0 0 1) ;血清TNF α含量中青年组与对照组比较无明显差异 (P >0 0 5 ) ,老年组明显增高 (P <0 0 1) ;老年组CSF中TNF α含量与周围血白细胞数及年龄有非常显著相关性 (r值分别为 0 5 0 47、0 6 2 0 5 ,P <0 0 1)。 结论 TNF
Objective Investigate the link between age and intracerebral tumor necrotic factor(TNF)changes in ischemic brain injury. Methods The enzyme linked immuno sorbent assay(ELISA)was used in the examination of cerebrospinal fluid(CSF)and serum TNF α in 45 cases of senile cerebral infarction and a comparison was made with those in 31 cases of middle age and juvenile cerebral infarction and 30 healthy cases. Results The TNF α level in CSF in senile groups of cerebral infarction is remarkably higher than that in the control group( P <0 01)and the middle age and juvenile group ( P <0 01);there is no difference of serum TNF α between the middle age group and the control group( P >0 05)while that in the senile group is remarkably higher( P <0 01).There is a remarkably link of TNF α in senile CSF with the surrounding blood leukocyte and the age( r values are 0 5047 and 0 6205 respectively, P <0 01). Conclusions The TNF α may be a pathogenic factor in senile cerebral infarction and an important factor in the worsening of ischemic brain injury.
出处
《实用老年医学》
CAS
2000年第2期78-79,共2页
Practical Geriatrics
关键词
脑梗塞
脑脊液
肿瘤坏死因子
病理
Cerebral infarction Cerebrospinal fluid Tumor necrotic factor
